{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:48:13Z","timestamp":1789926493044,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Heilongjiang Provincial Government Postdoctoral Science Foundation","award":["LBH-Z11060"],"award-info":[{"award-number":["LBH-Z11060"]}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["LC201005"],"award-info":[{"award-number":["LC201005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>Non\u2010alcoholic fatty liver disease (NAFLD<\/jats:styled-content>) is an independent risk factor for increased cardiovascular disease. The brachial\u2010ankle pulse wave velocity (baPWV<\/jats:styled-content>) is a marker for early atherosclerotic changes. Recently, the effect of changed blood rheology on atherosclerosis has received attention. A study confirmed that whole blood viscosity (WBV<\/jats:styled-content>) is a predictor of cardiovascular events. Therefore, this study aimed to investigate the association of WBV<\/jats:styled-content> with baPWV<\/jats:styled-content> in patients with NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>I<\/jats:styled-content>n this cross\u2010sectional study, the relationship between WBV<\/jats:styled-content> and baPWV<\/jats:styled-content> was investigated in 2032 participants (1035 men and 997 women) with NAFLD<\/jats:styled-content> in a general health examination.<\/jats:p><\/jats:sec>Results<\/jats:title>Different metabolic parameters were compared across WBV<\/jats:styled-content> (3\/s) quartiles. The mean values of baPWV<\/jats:styled-content> gradually increased with WBV<\/jats:styled-content> (3\/s) quartiles. Stepwise multiple linear regression analysis revealed that WBV<\/jats:styled-content> (3\/s) is a significant determinant for increased baPWV<\/jats:styled-content> both in men and in women (for male, \u03b2\u2009=\u20090.229; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001; for female, \u03b2\u2009=\u20090.672; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The findings showed that baPWV<\/jats:styled-content> elevated as WBV<\/jats:styled-content> (3\/s) increased in NAFLD<\/jats:styled-content>. Moreover, WBV<\/jats:styled-content> (3\/s) is independently associated with baPWV<\/jats:styled-content> even after adjusting other cardiovascular risk factors. Early detection of abnormal WBV<\/jats:styled-content> levels at low shear rate should warrant for early search of undetected arterial stiffness in patients with NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12368","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T11:18:44Z","timestamp":1377256724000},"page":"540-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Increased whole blood viscosity associated with arterial stiffness in patients with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Kai\u2010jiang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"},{"name":"International Physical Examination and Healthy Center The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e328354829c"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl312"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.359"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.158"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.05.033"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1059"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3233\/CH-2010-1367","article-title":"The effect of aging on blood and plasma viscosity. An 11.6 years follow\u2010up study","volume":"47","author":"Carallo C","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_10_1","first-page":"195","article-title":"Hemorheological parameters in correlation with the risk factors for carotid atherosclerosis","volume":"35","author":"Velcheva I","year":"2006","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/CH-2010-1275","article-title":"Sex\u2010dependent differences in rheological properties and the relation of blood viscosity to erythrocyte aggregation indices among morbidly obese patients","volume":"44","author":"Wiewiora M","year":"2010","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/CH-2011-1476","article-title":"Peripheral hemorheological and vascular correlates of coronary blood flow","volume":"49","author":"Damaske A","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.12.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/CH-2011-1480","article-title":"Microcirculation and blood rheology in patients with cerebrovascular disorders","volume":"49","author":"Tikhomirova IA","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3233\/CH-2011-1499","article-title":"Association between hemorheological alterations and metabolic syndrome","volume":"49","author":"Vaya A","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2011.565431"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3233\/CH-2011-1425","article-title":"Minimal model\u2010derived insulin sensitivity, insulin secretion and glucose tolerance: relationships with blood rheology","volume":"51","author":"Brun JF","year":"2012","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6402-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01649-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00998.2004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.144"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr453"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798764807"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.1.107"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920473"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH\u2010131702"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.252957"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:40:40Z","timestamp":1696272040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/jgh.12368"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12368","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]},"assertion":[{"value":"2013-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}