{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:09:09Z","timestamp":1761919749998,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172604"],"award-info":[{"award-number":["81172604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The presence of JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content> was reported to be associated with JAK<\/jats:styled-content>2 46\/1 haplotype, which was considered as an independent risk factor for B<\/jats:styled-content>udd\u2010C<\/jats:styled-content>hiari syndrome (BCS<\/jats:styled-content>) in Western countries. However, little is known in C<\/jats:styled-content>hina. Therefore, the aim of this study was to determine whether the 46\/1 haplotype is associated with such patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with primary BCS<\/jats:styled-content> and controls were consecutively admitted in our study from O<\/jats:styled-content>ctober 2009 to D<\/jats:styled-content>ecember 2012. The subjects were detected for the JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content> mutation by allele\u2010specific polymerase chain reaction (AS<\/jats:styled-content>\u2010PCR<\/jats:styled-content>) and the JAK<\/jats:styled-content>2 46\/1 haplotype by real\u2010time PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content> mutation was 2.37% (7\/295) in BCS<\/jats:styled-content> patients, and 46\/1 haplotype was overrepresented in JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content>\u2010positive BCS<\/jats:styled-content> patients compared with controls (P<\/jats:italic>\u2009<\u20090.01). The risk for the JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content>\u2010positive BCS<\/jats:styled-content> with CC<\/jats:styled-content> genotype was elevated compared with subjects presented TT<\/jats:styled-content> genotype (OR<\/jats:styled-content>\u2009=\u200913.4, 95%CI<\/jats:styled-content>\u2009=\u20092.01\u201389.5) and non\u2010CC<\/jats:styled-content> genotype (OR<\/jats:styled-content>\u2009=\u200915.0, 95%CI<\/jats:styled-content>\u2009=\u20092.45\u201391.7).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study showed that the presence of 46\/1 haplotype increased the risk of JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content>\u2010positive BCS<\/jats:styled-content> in C<\/jats:styled-content>hina. In addition, low prevalence of JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content> mutation in BCS<\/jats:styled-content> patients suggested that myeloproliferative neoplasms (MPN<\/jats:styled-content>s) should not be an etiological factor of BCS<\/jats:styled-content> in C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12379","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T11:22:43Z","timestamp":1377256963000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["JAK<\/scp>2 V<\/scp>617F<\/scp> mutation and 46\/1 haplotype in C<\/scp>hinese B<\/scp>udd\u2010C<\/scp>hiari syndrome patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoheng","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Affiliated Hospital of Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzhi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Affiliated Hospital of Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Public Health Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00434-8"},{"key":"e_1_2_6_5_1","first-page":"400","article-title":"Prothrombotic disorders in abdominal vein thrombosis","volume":"70","author":"Leebeek FW","year":"2012","journal-title":"Neth. 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