{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T10:58:56Z","timestamp":1788087536679,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>A customized screening program for gastric cancer would optimize the benefits of screening endoscopy. This study investigated the risk factors for gastric cancer detected during screening and factors affecting clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2000 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010, subjects who underwent screening endoscopy at <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>san <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter were included. To investigate risk factors, age\u2010 and sex\u2010matched control group was selected. The clinical outcomes of gastric cancer identified during screening (screening group) were compared with age, sex, and date of diagnosis\u2010matched subjects who were diagnosed with gastric cancer in the outpatient clinic (outpatient group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 109\u2009530 subjects, 327 were diagnosed with gastric cancer. The median age of the screening group was 63.6 years (interquartile range 56\u201371 years), and the male\u2010to\u2010female ratio was 2.4:1. When comparing with the control group, <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> seropositivity (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 2.933, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8.633, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), family history of gastric cancer (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.254, <jats:italic>P<\/jats:italic>\u2009=\u20090.007), and drinking (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.312, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were independent positive risk factors, and the use of aspirin a negative risk factor for gastric cancer (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.445, <jats:italic>P<\/jats:italic>\u2009=\u20090.012) in multivariate analysis. Low\u2010density lipoprotein cholesterol (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 0.987, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), cancer antigen 19\u20109 (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 21.713, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), resectability (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 59.833, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and family history (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.308, <jats:italic>P<\/jats:italic>\u2009=\u20090.009) were independent risk factors for death. The 5\u2010year survival rate was significantly higher in the screening group than in the outpatient group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early detection of gastric cancer by screening endoscopy while asymptomatic enhances patient outcomes, especially in high\u2010risk groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12387","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:03:37Z","timestamp":1381543417000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Risk factors and clinical outcomes of gastric cancer identified by screening endoscopy: A case\u2013control study"],"prefix":"10.1111","volume":"29","author":[{"given":"Eun Jeong","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwi\u2010Sook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho June","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son Yeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Health Screening &amp; 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