{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:22:42Z","timestamp":1792498962166,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Oxidative stress and inflammation play important roles in the progression from simple fatty liver to non\u2010alcoholic steatohepatitis (<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>). The aim of this work was to investigate whether treatment with hydrogen sulfide (<jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content>) prevented <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> in rats through abating oxidative stress and suppressing inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A methionine\u2010choline\u2010deficient (<jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>) diet rat model was prepared. Rats were divided into three experimental groups and fed for 8 weeks as follows: (i) control rats; (ii) <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet\u2010fed rats; (iii) <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet\u2010fed rats treated with <jats:styled-content style=\"fixed-case\">NaHS<\/jats:styled-content> (intraperitoneal injection of 0.1\u2009mL\/kg\/day of 0.28\u2009mol\/L <jats:styled-content style=\"fixed-case\">NaHS<\/jats:styled-content>, a donor of <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> diet impaired hepatic <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content> biosynthesis in rats. Treatment with <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content> prevented <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet\u2010induced <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>, as evidenced by hematoxylin and eosin staining, reduced apoptosis and activities of alanine aminotransferase and aspartate aminotransferase, and attenuated hepatic fat accumulation in rats. Treatment with <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content> abated <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet\u2010induced oxidative stress through reducing cytochrome p4502<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>1 expression, enhancing heme oxygenase\u20101 expression, and suppressing mitochondrial reactive oxygen species formation, and suppressed <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet\u2010induced inflammation through suppressing activated nuclear factor <jats:styled-content style=\"fixed-case\">\u03baB<\/jats:styled-content> signaling and reducing interleukin\u20106 and tumor necrosis factor \u03b1 expressions. In addition, treatment of <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>\u2010diet fed rats with <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content> had a beneficial modulation on expression profiles of fatty acid metabolism genes in livers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content> prevented <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> induced by <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> diet in rats possibly through abating oxidative stress and suppressing inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12389","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:37:35Z","timestamp":1381545455000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effects of treatment with hydrogen sulfide on methionine\u2010choline deficient diet\u2010induced non\u2010alcoholic steatohepatitis in rats"],"prefix":"10.1111","volume":"29","author":[{"given":"Zhu\u2010Lin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"},{"name":"Graduate School The Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Wu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Dong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Zhou","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of General Surgery General Hospital of Chengdu Military Command  Chengdu Sichuan Province 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