{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:43:30Z","timestamp":1790804610566,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Upfront liver transplantation is the gold standard in the treatment of patients with hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) and cirrhosis, but a shortage of donor organs negatively impacts on survival outcomes, with significant disease progression during long waiting lists. This systematic review evaluates the safety and efficacy of salvage liver transplantation (<jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>) as treatment for recurrent <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> after initial hepatic resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ubmed, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mbase, and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edline databases identified 130 abstracts, from which 16 eligible studies comprising 319 patients were selected for review. Studies adopting <jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content> following primary hepatic resection for recurrent <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> with more than five patients were included. Demographic details, morbidity and mortality indices, and survival outcomes were collected from each study and were tabulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients included in the studies had liver cirrhosis, with the majority being <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh A (50%) and B (33%). The etiology of liver disease was hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> in the majority of patients (84%). Disease recurrence occurred in 27\u201380% of patients at a median of 21.4 months (range 14.5\u201334) following initial resection. <jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content>s were performed on 41% of recurrences, and were associated with biliary complications (8%), infection (11%), bleeding (8%), and vascular complications (7%). There were 18 perioperative deaths (5.6%). The median 1\u2010, 3\u2010, and 5\u2010year overall and disease\u2010free survival was 89%, 80%, and 62%, and 86%, 68%, and 67%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Synthesis of available observational studies suggests that <jats:styled-content style=\"fixed-case\">SLT<\/jats:styled-content> following primary hepatic resection is a highly applicable strategy with long\u2010term survival outcomes that are comparable to upfront liver transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12399","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:34:34Z","timestamp":1381545274000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Systematic review of efficacy and outcomes of salvage liver transplantation after primary hepatic resection for hepatocellular carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Daniel L","family":"Chan","sequence":"first","affiliation":[{"name":"Hepatobiliary and Surgical Oncology Unit UNSW Department of Surgery St George Hospital  Sydney New South Wales Australia"},{"name":"St George Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"The Systematic Review Unit The Collaborative Research (CORE) Group  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayef A","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Surgical Oncology Unit UNSW Department of Surgery St George Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Morris","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Surgical Oncology Unit UNSW Department of Surgery St George Hospital  Sydney New South Wales Australia"},{"name":"St George Clinical School University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence C","family":"Chua","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Surgical Oncology Unit UNSW Department of Surgery St George Hospital  Sydney New South Wales Australia"},{"name":"St George Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"The Systematic Review Unit The Collaborative Research (CORE) Group  Sydney New South Wales Australia"},{"name":"Department of Surgery Manly Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001683"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"e_1_2_5_5_1","first-page":"83","article-title":"Donor difficulties in Japan and Asian countries","volume":"27","author":"Ota K","year":"1995","journal-title":"Transplant. 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