{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:25:19Z","timestamp":1769923519137,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Presidential Body of the Himalayan Institute Hospital Trust, Dehradun, Uttarakhand, India"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>addrey <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iscriminant <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>unction (<jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content>) score and the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odel for <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nd\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tage <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) score are standard prognostic scores for predicting disease severity and mortality in alcoholic hepatitis (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>).This prospective study compared the <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score and the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score as predictors of short\u2010term outcome in <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The admission <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score and the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score were assessed in 47 patients with a diagnosis of <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>imalayan <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nstitute <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital, <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ehradun, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndia and the concordance (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) statistics of the two scores for 28\u2010day mortality were determined and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score and the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score on day 1 were significantly higher in non\u2010survivors than in survivors (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001 each). The <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010statistic for 28\u2010day mortality for the <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score was 0.91 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.79\u20130.97) and for the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score 0.90 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20130.97). There was no significant difference between the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010statistics of the two scores (<jats:italic>P<\/jats:italic>\u2009=\u20090.83, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.07 to 0.09). For predicting 28\u2010day mortality, the optimal <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score of &gt;\u200919 (sensitivity 91.6% and specificity 85.7%) corresponded to the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score of &gt;\u200952.8 (sensitivity 91.6% and specificity 82.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both the <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score and the <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score at admission were strong and equally good predictors of 28\u2010day mortality in patients with <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>, but the optimal <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score corresponding to optimal <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score was higher than the conventional one. Thus, <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score may be used as an alternative to <jats:styled-content style=\"fixed-case\">mDF<\/jats:styled-content> score for predicting short\u2010term mortality in <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> with an advantage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12400","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:43:50Z","timestamp":1381545830000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>M<\/scp>odel for <scp>E<\/scp>nd\u2010<scp>S<\/scp>tage <scp>L<\/scp>iver <scp>D<\/scp>isease score versus <scp>M<\/scp>addrey <scp>D<\/scp>iscriminant <scp>F<\/scp>unction score in assessing short\u2010term outcome in alcoholic hepatitis"],"prefix":"10.1111","volume":"29","author":[{"given":"Monil","family":"Kadian","sequence":"first","affiliation":[{"name":"Department of Medicine Himalayan Institute of Medical Sciences  Dehradun Uttarakhand India"},{"name":"HIHT University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Medicine Himalayan Institute of Medical Sciences  Dehradun Uttarakhand India"},{"name":"HIHT University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minakshi","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Medicine Himalayan Institute of Medical Sciences  Dehradun Uttarakhand India"},{"name":"HIHT University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev Mohan","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Medicine Himalayan Institute of Medical Sciences  Dehradun Uttarakhand India"},{"name":"HIHT University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i12.335"},{"key":"e_1_2_8_3_1","unstructured":"Global Status Report on Alcohol 2011. 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