{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:20:36Z","timestamp":1790364036751,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia"},{"name":"Austin Hospital Medical Research Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>An increase in circulating concentrations of gastrin or gastrin precursors such as progastrin and glycine\u2010extended gastrin has been proposed to promote the development of colorectal carcinomas (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>). The aim of this study was to investigate whether or not circulating gastrin concentrations were increased in patients with an increased risk of developing <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients were divided according to their risk into the five following groups: familial adenomatous polyposis (<jats:italic>n<\/jats:italic>\u2009=\u200920), hereditary non\u2010polyposis colorectal cancer (<jats:italic>n<\/jats:italic>\u2009=\u200953), cluster of common colorectal cancers (<jats:italic>n<\/jats:italic>\u2009=\u200913), personal history and\/or family history of adenomatous polyps or <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u2009150) and controls (<jats:italic>n<\/jats:italic>\u2009=\u200942). Radioimmunoassay with four region\u2010specific gastrin antisera was used to measure progastrin, glycine\u2010extended gastrin (gastrin\u2010gly), amidated gastrin (gastrin\u2010amide), and total gastrin in peripheral blood taken at the time of colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group, familial adenomatous polyposis patients had significantly higher median values of total gastrin (29.8\u2009<jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content>\u2005<jats:italic>vs<\/jats:italic> 16.9\u2009<jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and gastrin\u2010amide (17.1\u2009<jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content>\u2005<jats:italic>vs<\/jats:italic> 12.0\u2009<jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.015). Patients with a personal or family history of adenomatous polyps or <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> also had higher circulating concentrations of total gastrin (21.8\u2009<jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content>) compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while patients from all groups who presented with an adenomatous polyp on the day of colonoscopy had higher concentrations of total gastrin, progastrin, and gastrin\u2010amide than patients without polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concentrations of gastrin precursors are increased in particular groups with an increased risk of developing <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12417","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T11:22:56Z","timestamp":1382354576000},"page":"480-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Adrienne C","family":"Paterson","sequence":"first","affiliation":[{"name":"Department of Surgery Austin Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay A","family":"Macrae","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Melbourne Health  Melbourne Victoria 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