{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:04:28Z","timestamp":1791043468502,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81273552"],"award-info":[{"award-number":["81273552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Science and Technology commission","award":["12ZCZDSY02700"],"award-info":[{"award-number":["12ZCZDSY02700"]}]},{"name":"Tianjin Science and Technology commission","award":["13JCYBJC22500"],"award-info":[{"award-number":["13JCYBJC22500"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Recent studies have shown that imbalance between tumor\u2010infiltrating interleukin (IL<\/jats:styled-content>)\u201017+<\/jats:sup> T<\/jats:styled-content> cells and regulatory T<\/jats:styled-content> cells (T<\/jats:styled-content>regs) is an important regulator of progression in various cancers, but little is known regarding this imbalance in hepatocellular carcinoma (HCC<\/jats:styled-content>). This study explored the role of imbalance between IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells and T<\/jats:styled-content>regs in the immunopathogenesis of HCC<\/jats:styled-content> in patients with chronic hepatitis B<\/jats:styled-content> (CHB<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty\u2010six of patient\u2010matched tumors and peritumoral surgical specimens from 56 patient with HCC<\/jats:styled-content> and 136 liver biopsies specimens from 46 patients with CHB<\/jats:styled-content>, 37 with atypical hyperplasia (AH<\/jats:styled-content>), and 53 with HCC<\/jats:styled-content> were enrolled. The expressions of IL<\/jats:styled-content>\u201017, F<\/jats:styled-content>oxP<\/jats:styled-content>3, CD<\/jats:styled-content>4, and CD<\/jats:styled-content>8 in liver tissue were measured by immunochemistry for the evaluation of liver\u2010infiltrating lymphocytes.<\/jats:p><\/jats:sec>Results<\/jats:title>The density of liver infiltrated F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup> T<\/jats:styled-content>regs was increased in a stepwise manner from CHB<\/jats:styled-content> to AH<\/jats:styled-content> then HCC<\/jats:styled-content>, while there was a decreasing trend for the density of IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells and CD<\/jats:styled-content>8+<\/jats:sup> T<\/jats:styled-content> cells. In surgical specimens of less differentiated HCC<\/jats:styled-content>, the quantity of tumor\u2010infiltrating F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup> T<\/jats:styled-content>regs was significantly lower and IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells and CD<\/jats:styled-content>8+<\/jats:sup> T<\/jats:styled-content> cells were significantly higher. Additionally, peritumoral IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells were increased in poorly differentiated HCC<\/jats:styled-content>. High intratumoral F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup> T<\/jats:styled-content>regs with high intratumoral IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells showed a significantly lower overall survival (OS<\/jats:styled-content>) and disease\u2010free survival (DFS<\/jats:styled-content>) compared with other groups (OS<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.033; DFS<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.004). High intratumoral F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup> T<\/jats:styled-content>regs with high peritumoral IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells showed a significantly lower survival rate compared with other groups (OS<\/jats:styled-content>, P<\/jats:italic>\u2009<\u20090.001 and DFS<\/jats:styled-content>, P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest that intrahepatic IL<\/jats:styled-content>\u201017+<\/jats:sup> T<\/jats:styled-content> cells and F<\/jats:styled-content>oxP<\/jats:styled-content>3+<\/jats:sup> T<\/jats:styled-content>regs may cooperate to promote the progression of HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12418","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T11:23:04Z","timestamp":1382354584000},"page":"851-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Intrahepatic interleukin\u201017+<\/sup>T<\/scp> cells and F<\/scp>oxP<\/scp>3+<\/sup> regulatory T cells cooperate to promote development and affect the prognosis of hepatocellular carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Yong","family":"Huang","sequence":"first","affiliation":[{"name":"The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Department of Hepatobiliary Surgery Institute of Hepatobiliary Disease Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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