{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:34:46Z","timestamp":1790249686594,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid on\u2010site evaluation (<jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content>) has the potential to improve adequacy rates for endoscopic ultrasound\u2010guided fine needle aspiration (<jats:styled-content style=\"fixed-case\">EUS\u2010FNA<\/jats:styled-content>) of solid pancreatic lesions, but its impact is context\u2010dependent. No studies exist that summarize the relationship between <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content>, number of needle passes, and resulting adequacy rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To analyze data from previous studies to establish if <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> is associated with improved adequacy rates; to evaluate the relationship between <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content>, number of needle passes, and the resulting adequacy rates of <jats:styled-content style=\"fixed-case\">EUS\u2010FNA<\/jats:styled-content> for solid pancreatic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review and meta\u2010analysis of studies reporting the adequacy rates for <jats:styled-content style=\"fixed-case\">EUS\u2010FNA<\/jats:styled-content> of solid pancreatic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search produced 3822 original studies, of which 70 studies met our inclusion criteria. The overall average adequacy rate was 96.2% (95% confidence interval: 95.5, 96.9). <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> was associated with a statistically significant improvement of up to 3.5% in adequacy rates. There was heterogeneity in adequacy rates across all subgroups. No association between the assessor type and adequacy rates was found. Studies with <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> have high per\u2010case adequacy and a relatively high number of needle passes in contrast to non\u2010<jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> studies. <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> is an effect modifier of the relationship between number of needle passes and adequacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> is associated with up to 3.5% improvement in adequacy rates for <jats:styled-content style=\"fixed-case\">EUS\u2010FNA<\/jats:styled-content> of solid pancreatic lesions. <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> assessor type has no impact on adequacy rates. <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> is an effect modifier on the relationship between needle passes and per\u2010case adequacy for <jats:styled-content style=\"fixed-case\">EUS\u2010FNA<\/jats:styled-content> of solid pancreatic lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12431","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T10:54:05Z","timestamp":1384858445000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Impact of rapid on\u2010site evaluation on the adequacy of endoscopic\u2010ultrasound guided fine\u2010needle aspiration of solid pancreatic lesions: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Anna P","family":"Matynia","sequence":"first","affiliation":[{"name":"Department of Pathology University of Utah School of Medicine and ARUP Laboratories  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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