{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:55:35Z","timestamp":1779317735040,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Chinese National Nature Science Foundation","doi-asserted-by":"crossref","award":["81170372"],"award-info":[{"award-number":["81170372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Nature Science Foundation","doi-asserted-by":"crossref","award":["81070326"],"award-info":[{"award-number":["81070326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Foundation for Social Development from Shaanxi Province, China","award":["2011K12-38"],"award-info":[{"award-number":["2011K12-38"]}]},{"name":"Scientific Technology Innovation Foundation from Shaanxi Province, China","award":["2011KTCL03-09"],"award-info":[{"award-number":["2011KTCL03-09"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Primary biliary cirrhosis (PBC<\/jats:styled-content>) is a chronic and progressive cholestatic autoimmune liver disease. Although many studies have evaluated the association between many functional polymorphisms in the vitamin D<\/jats:styled-content> receptor (VDR<\/jats:styled-content>) gene and PBC<\/jats:styled-content> risk, debates still exist. Our aim is to evaluate the association between VDR<\/jats:styled-content> gene polymorphisms, including TaqI<\/jats:styled-content> (rs731236), BsmI<\/jats:styled-content> (rs1544410), and ApaI<\/jats:styled-content> (rs7975232), and the risk of PBC<\/jats:styled-content> by a systematic review.<\/jats:p><\/jats:sec>Methods<\/jats:title>We searched literatures in P<\/jats:styled-content>ubM<\/jats:styled-content>ed, SCOPUS<\/jats:styled-content>, and EMBASE<\/jats:styled-content> until J<\/jats:styled-content>uly 2013. We calculated pooled odds ratios (OR<\/jats:styled-content>) and 95% confidence intervals (CI<\/jats:styled-content>s) using a fixed effects model or a random effects model for the risk to PBC<\/jats:styled-content> associated with different VDR<\/jats:styled-content> gene polymorphisms. And the heterogeneity assumption decided the effect model.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of six relevant studies, with 1322 PBC<\/jats:styled-content> cases and 2264 controls, were included in this meta\u2010analysis. The results indicated that TaqI<\/jats:styled-content> (rs731236) polymorphism was significantly associated with PBC<\/jats:styled-content> risk (for T vs<\/jats:italic> t OR<\/jats:styled-content>\u2009=\u20090.75, 95% CI<\/jats:styled-content> 0.63, 0.89, Pz<\/jats:styled-content>\u2009=\u20090.001; TT<\/jats:styled-content>\u2009+\u2009Tt vs<\/jats:italic> tt OR<\/jats:styled-content>\u2009=\u20090.62, 95% CI<\/jats:styled-content> 0.44, 0.86, Pz =\u20090.005; OR<\/jats:styled-content>\u2009=\u20090.74, 95% CI<\/jats:styled-content> 0.58, 0.94, Pz =\u20090.016 for recessive model), while ApaI<\/jats:styled-content> (rs7975232) or BsmI<\/jats:styled-content> (rs1544410) polymorphism did not.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Based on current evidences from published studies, the cumulative effect of TaqI<\/jats:styled-content> polymorphism in VDR<\/jats:styled-content> was significantly associated with PBC<\/jats:styled-content>. Larger studies with mixed ethnicity subjects and stratified by clinical and sub clinical characteristics are needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12443","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T02:50:43Z","timestamp":1384397443000},"page":"706-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Polymorphisms in the vitamin D<\/scp> receptor gene and risk of primary biliary cirrhosis: A meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Yuan\u2010jun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Student Bridge I of Aerospace Medicine Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010quan","family":"Shi","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Han","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology Fourth Military Medical University Xi'an 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