{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:22:46Z","timestamp":1754396566415},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Gastric ulcer healing is a complex process involving cell proliferation and tissue remodeling. Sonic hedgehog (S<\/jats:styled-content>hh) activates the S<\/jats:styled-content>hh signaling pathway, which plays a key role in processes such as tissue repair. S<\/jats:styled-content>hh and interleukin 1\u03b2 (IL<\/jats:styled-content>1\u03b2) have been reported to influence the proliferation of gastric mucosa. We evaluated the relationships between the speed of gastric ulcer healing and the levels of expression of S<\/jats:styled-content>hh and IL<\/jats:styled-content>1\u03b2.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study included 45 patients (mean age 71.9\u2009\u00b1\u20099.0 years; M<\/jats:styled-content>\/F<\/jats:styled-content>, 30\/15) who underwent endoscopic submucosal dissection (ESD<\/jats:styled-content>) for gastric cancer, followed by standard dose of oral proton\u2010pump inhibitor for 4 weeks. Subsequently, the size of ESD<\/jats:styled-content>\u2010induced artificial ulcers were measured to determine the speed of gastric ulcer healing, and regenerating mucosa around the ulcers and appropriately matched controls were collected from patients by endoscopic biopsy. Polymerase chain reaction (PCR) array analysis of genes in the Shh signaling pathway was performed, and quantitative reverse transcription (RT)\u2010PCR was used to measure IL<\/jats:styled-content>1\u03b2 mRNA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The levels of S<\/jats:styled-content>hh and IL<\/jats:styled-content>1\u03b2 mRNA<\/jats:styled-content> were 3.0\u2009\u00b1\u20092.7\u2010fold and 2.5\u2009\u00b1\u20092.5\u2010fold higher, respectively, in regenerating mucosa of artificial ulcers than in appropriately matched controls, with the two being positively correlated (r\u2009=\u20090.9, P<\/jats:italic>\u2009<\u20090.001). S<\/jats:styled-content>hh (r\u2009=\u20090.8, P<\/jats:italic>\u2009<\u20090.001) and IL<\/jats:styled-content>1\u03b2 (r\u2009=\u20090.7, P<\/jats:italic>\u2009<\u20090.005) expression was each positively correlated with the speed of gastric ulcer healing, but multivariate analysis showed that Shh expression was the only significant parameter (P<\/jats:italic>\u2009=\u20090.045).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Expression of S<\/jats:styled-content>hh was correlated with the speed of gastric ulcer healing, promoting the regeneration of gastric mucosa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12445","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T02:50:42Z","timestamp":1384397442000},"page":"736-741","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers"],"prefix":"10.1111","volume":"29","author":[{"given":"Takeshi","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Molecular Oncology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Minemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arata","family":"Oyamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Chiba 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