{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:59Z","timestamp":1788871199429,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NMRP890081"],"award-info":[{"award-number":["NMRP890081"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Patients with gastroesophageal reflux disease (\n GERD<\/jats:styled-content>\n ) are often advised to avoid large meals, based on their complaints of increased symptoms after eating too much, and epidemiological evidence of a link between high volume intake and the presence of\n GERD<\/jats:styled-content>\n . However, the precise effects of meal volume on gastroesophageal reflux have not been well studied. We aimed to clarify the effect of meal volume on acid regurgitation and symptoms in patients with\n GERD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifteen patients (10 female, 5 male; mean 54\u2009\u00b1\u200910 years old) with\n GERD<\/jats:styled-content>\n were studied twice each in random order, during 24\u2009h ambulatory\n pH<\/jats:styled-content>\n monitoring. On one day, they consumed a 600\u2009\n mL<\/jats:styled-content>\n liquid test meal three times (breakfast, lunch, and dinner), and on the other, they consumed a 300\u2009\n mL<\/jats:styled-content>\n test meal six times (breakfast, snack, lunch, snack, dinner, and snack). Gastric fundus and antral areas and antral contractions were measured by transabdominal ultrasound. Symptoms were recorded using questionnaires.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During the 600\u2009\n mL<\/jats:styled-content>\n regimen, there were more reflux episodes (17\u2009\u00b1\u20094\n vs<\/jats:italic>\n 10\u2009\u00b1\u20092,\n P<\/jats:italic>\n \u2009=\u20090.03) and a greater total acid reflux time (12.5\u2009\u00b1\u20095.9%\n vs<\/jats:italic>\n 5.5\u2009\u00b1\u20093.6%;\n P<\/jats:italic>\n \u2009=\u20090.045) than the 300\u2009\n mL<\/jats:styled-content>\n regimen. Both the cross\u2010sectional area of the gastric fundus (\n P<\/jats:italic>\n \u2009=\u20090.024) and the number of antral contractions (\n P<\/jats:italic>\n \u2009=\u20090.014) were greater for the 600\u2009\n mL<\/jats:styled-content>\n regimen.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Larger meals are associated with distension of the gastric fundus and an increase in gastroesophageal reflux when compared with smaller, more frequent meals.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12457","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T04:46:38Z","timestamp":1384490798000},"page":"469-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of liquid meals with different volumes on gastroesophageal reflux disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Keng\u2010Liang","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Rayner","sequence":"additional","affiliation":[{"name":"Discipline of Medicine, Royal Adelaide Hospital University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng\u2010Kee","family":"Chuah","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King\u2010Wah","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung Memorial Hospital Kaohsiung Taiwan"},{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Tang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Chang Gung University College of Medicine Kaohsiung 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