{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:02:16Z","timestamp":1767970936362,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for JFE"},{"name":"JSPS KAKENHI","award":["13279779"],"award-info":[{"award-number":["13279779"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Medical treatment for inflammatory bowel disease (IBD<\/jats:styled-content>) requires chronic administration and causes side effects. Recently, anti\u2010inflammatory effects of phototherapy were reported in animal models. The present study evaluated whether phototherapy improves dextran sulfate sodium (DSS<\/jats:styled-content>)\u2010induced colitis in a mouse model of IBD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Mice were divided into four equal groups: Control, DSS<\/jats:styled-content>, DSS<\/jats:styled-content>\u2009+\u2009light low (LL<\/jats:styled-content>), and DSS<\/jats:styled-content>\u2009+\u2009light high (LH<\/jats:styled-content>) groups. Normal fluorescent light intensity in the Control and DSS<\/jats:styled-content> groups was 200 lux. Artificial light intensities were as follows: DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> group, 1000 lux; DSS<\/jats:styled-content>\u2009+\u2009LH<\/jats:styled-content> group, 2500 lux. After administering phototherapy for 7 days, we evaluated disease activity index (DAI<\/jats:styled-content>), histological score, colon length\/weight, serum 1,25\u2010dihydroxyvitamin D<\/jats:styled-content>(3) level, and serum and colonic cytokines in the mice.<\/jats:p><\/jats:sec>Results<\/jats:title>DAI<\/jats:styled-content> and histological scores were significantly lower in the DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> group than in the DSS<\/jats:styled-content> group (both, P<\/jats:italic>\u2009<\u20090.05). Colon length and weight were significantly higher in the DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> group than in the DSS<\/jats:styled-content> group (both, P<\/jats:italic>\u2009<\u20090.05). Serum interleukin (IL<\/jats:styled-content>)\u20106, TNF<\/jats:styled-content>\u2010\u03b1, and IL<\/jats:styled-content>\u201017 in the DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> group were significantly lower, and serum and colonic IL<\/jats:styled-content>\u201010 were significantly higher in the DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> group than in the DSS<\/jats:styled-content> group (all, P<\/jats:italic>\u2009<\u20090.05). Serum 1,25\u2010dihydroxyvitamin D<\/jats:styled-content>(3) levels in the DSS<\/jats:styled-content>\u2009+\u2009LH<\/jats:styled-content> group were significantly increased compared with those in the DSS<\/jats:styled-content>\u2009+\u2009LL<\/jats:styled-content> and DSS<\/jats:styled-content> groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Artificial light phototherapy suppressed DSS<\/jats:styled-content>\u2010induced colitis in mice by suppression of pro\u2010inflammatory cytokines and promotion of anti\u2010inflammatory cytokines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12460","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T09:46:42Z","timestamp":1384508802000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Phototherapy with artificial light suppresses dextran sulfate sodium\u2010induced colitis in a mouse model"],"prefix":"10.1111","volume":"29","author":[{"given":"Takahiro","family":"Hiratsuka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Goto","sequence":"additional","affiliation":[{"name":"Liver Transplantation Program Chang Gung Memorial Hospital\u2010Kaohsiung Medical Center Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Oita University Faculty of Medicine Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Liver Transplantation Program Chang Gung Memorial Hospital\u2010Kaohsiung Medical Center Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Liver Transplantation Program Chang Gung Memorial Hospital\u2010Kaohsiung Medical Center Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Oita University Faculty of Medicine Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Kitano","sequence":"additional","affiliation":[{"name":"Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07150.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01999.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20728"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.07.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0708376"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2009.04.025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.028"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030655"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jdermsci.2011.12.009","article-title":"The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: implications for autoimmunity","volume":"66","author":"Halliday GM","journal-title":"J. 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