{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:49:37Z","timestamp":1777538977404,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia (NHMRC) Project","award":["400920"],"award-info":[{"award-number":["400920"]}]},{"name":"National Health and Medical Research Council of Australia (NHMRC) Project","award":["510448"],"award-info":[{"award-number":["510448"]}]},{"name":"School of Medical Sciences, University of NSW"},{"name":"NHMRC Practitioner Fellowship","award":["510246"],"award-info":[{"award-number":["510246"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Chronic hepatitis C<\/jats:styled-content> virus infection is characterized by infiltration of a mixed population of leukocytes into portal tracts and infiltration almost exclusively by CD<\/jats:styled-content>8+ T<\/jats:styled-content> cells into lobules of the liver. This pattern of leukocyte recruitment is likely to be orchestrated in a cell\u2010specific fashion by local chemokine expression.<\/jats:p><\/jats:sec>Methods<\/jats:title>Portal or lobular tissues were isolated by laser capture microdissection from 17 liver biopsy specimens to examine regional gene expression of a panel of chemokine ligands and receptors. The biopsies were also stained immunohistochemically to enumerate regional cell numbers.<\/jats:p><\/jats:sec>Results<\/jats:title>Expression of multiple chemokine ligands and receptors was evident, although few correlated with leukocyte numbers. In the lobule, expression of CXCL<\/jats:styled-content>10 correlated with T<\/jats:styled-content>\u2010cell subsets (CD<\/jats:styled-content>3+, P<\/jats:italic>\u2009=\u20090.0002; CD<\/jats:styled-content>4+, P<\/jats:italic>\u2009=\u20090.0053; and CD<\/jats:styled-content>8+, P<\/jats:italic>\u2009=\u20090.0061), as did CCL<\/jats:styled-content>5 (CD<\/jats:styled-content>3+, P<\/jats:italic>\u2009=\u20090.0005; CD<\/jats:styled-content>8+, P<\/jats:italic>\u2009=\u20090.0199) and CCL<\/jats:styled-content>3 (CD<\/jats:styled-content>3+, P<\/jats:italic>\u2009=\u20090.0016; CD<\/jats:styled-content>8+, P<\/jats:italic>\u2009=\u20090.008). In the portal tracts, expression of CXCL<\/jats:styled-content>10 and CCL<\/jats:styled-content>5 was correlated with CD<\/jats:styled-content>8+ T<\/jats:styled-content>\u2010cell numbers (P<\/jats:italic>\u2009=\u20090.0040 and P<\/jats:italic>\u2009=\u20090.0114, respectively), whereas CXCL<\/jats:styled-content>13 was strongly correlated with CD<\/jats:styled-content>20+ B<\/jats:styled-content>\u2010cell numbers (P<\/jats:italic>\u2009<\u20090.0001). CXCR<\/jats:styled-content>3 expression correlated with CD<\/jats:styled-content>3+ and CD<\/jats:styled-content>4+ T<\/jats:styled-content> cells (P<\/jats:italic>\u2009<\u20090.0001 and P<\/jats:italic>\u2009=\u20090.0208, respectively), CCR<\/jats:styled-content>5 with CD<\/jats:styled-content>8+ T<\/jats:styled-content> cells (P<\/jats:italic>\u2009<\u20090.0001), and CXCR<\/jats:styled-content>5 with CD<\/jats:styled-content>20+ B<\/jats:styled-content>\u2010cell infiltration (P<\/jats:italic>\u2009=\u20090.0022).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CXCR<\/jats:styled-content>3, CCR<\/jats:styled-content>5, and CXCR<\/jats:styled-content>5 and their ligands form key elements of the \u201czip code\u201d responsible for regional localization of specific lymphocyte subsets in the HCV<\/jats:styled-content>\u2010infected liver.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12462","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T09:46:42Z","timestamp":1384508802000},"page":"860-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Positioning of leukocyte subsets in the portal and lobular compartments of hepatitis C virus\u2010infected liver correlates with local chemokine expression"],"prefix":"10.1111","volume":"29","author":[{"given":"Nam","family":"Nguyen","sequence":"first","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"de Esch","sequence":"additional","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cameron","sequence":"additional","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh K","family":"Kumar","sequence":"additional","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany","family":"Zekry","sequence":"additional","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"},{"name":"St George Hospital Clinical School University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Inflammation and Infection Research Centre School of Medical Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.01036.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00945023"},{"key":"e_1_2_6_4_1","first-page":"963","article-title":"Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. 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