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This study evaluated the clinical and endoscopic features of the pathological subtypes of PGITL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010two lesions in 36 patients with PGITL<\/jats:styled-content> were assessed, including 15 enteropathy\u2010associated T<\/jats:styled-content>\u2010cell lymphomas (EATL<\/jats:styled-content>), 13 peripheral T<\/jats:styled-content>\u2010cell lymphomas (PTCL<\/jats:styled-content>), 10 NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphomas (NK<\/jats:styled-content>\/TL<\/jats:styled-content>), and four anaplastic large cell lymphomas (ALCL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>PTCL<\/jats:styled-content> occurred more frequently in the stomach and duodenum and NK<\/jats:styled-content>\/TL<\/jats:styled-content> more frequently in the small and large intestines (P<\/jats:italic>\u2009=\u20090.009). The endoscopic features of the four subtypes were similar (P<\/jats:italic>\u2009=\u20090.124). Fifteen of 41 lesions (36.6%) were E<\/jats:styled-content>pstein\u2013B<\/jats:styled-content>arr virus (EBV<\/jats:styled-content>) positive, with NK<\/jats:styled-content>\/TL<\/jats:styled-content> more likely to be EBV<\/jats:styled-content> positive than the other types (P<\/jats:italic>\u2009<\u20090.001). First endoscopy and first computed tomography (CT<\/jats:styled-content>) scan indicated that 65.4% and 51.4% of the lesions, respectively, were malignant, and that 43.2% and 42.3%, respectively, were GI<\/jats:styled-content> lymphomas. The two modalities together correctly diagnosed about half of the lesions before biopsy. Intestinal perforation was associated with small bowel location (P<\/jats:italic>\u2009<\u20090.001) and infiltrative type (P<\/jats:italic>\u2009=\u20090.009), and was more common in NK<\/jats:styled-content>\/TL<\/jats:styled-content> than in the other subtypes (P<\/jats:italic>\u2009=\u20090.015). Multivariate analysis showed that higher international prognosis index (P<\/jats:italic>\u2009=\u20090.008) and the presence of complications (P<\/jats:italic>\u2009=\u20090.006) were associated with poor prognosis. Survival was poorer in patients with small bowel lesions than with lesions at other locations (P<\/jats:italic>\u2009=\u20090.048).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The four main pathological types of PGITL<\/jats:styled-content> differed in clinical characteristics. As PGITL<\/jats:styled-content> was often not diagnosed by initial endoscopic or radiological examination, a high index of suspicion is necessary to ensure its early diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12471","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T02:24:45Z","timestamp":1386728685000},"page":"934-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Endoscopic and clinical analysis of primary T<\/scp>\u2010cell lymphoma of the gastrointestinal tract according to pathological subtype"],"prefix":"10.1111","volume":"29","author":[{"given":"Do Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danbi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of 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