{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:28:29Z","timestamp":1765704509769,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30872409"],"award-info":[{"award-number":["30872409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Elastography point quantification (<jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content>) was a newly non\u2010invasive method for the assessment of liver fibrosis by measuring liver stiffness. We aimed at evaluating the reproducibility of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> technology in the determination of liver stiffness and to investigate the value of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> in liver fibrosis staging among chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 291 successive patients who underwent liver partial hepatectomy or biopsy were examined with the <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> technology for the measurement of liver stiffness. Ten <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> measurements were obtained in the right lobe of the liver through the seventh to the tenth intercostal space for every patient. The reproducibility of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> technology was analyzed with intraclass correlation (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) of reliability analysis. Comparing the median of 10 measurements of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> with liver fibrosis, necroinflammatory activity, and steatosis pathologically, as well as gender and age, potential factors affecting liver stiffness were explored by multiple linear regression analysis, and the performances of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> were evaluated with repeated measures <jats:sc>anova<\/jats:sc> and receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> of 10 measurements of liver stiffness with <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> technique was 0.798, which indicated a good reproducibility. Liver fibrosis and necroinflammatory activity were positively correlated with <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.00, 0.01\u2009&lt;\u20090.05) while other factors had no effect on <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content>. There was significant difference of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>1 (5.60\u2009\u00b1\u20092.55\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>2 (7.44\u2009\u00b1\u20093.43\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u2009=\u20090.01\u2009&lt;\u20090.05), and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>3 (8.71\u2009\u00b1\u20093.14\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>4 (10.87\u2009\u00b1\u20095.25\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u2009=\u20090.01\u2009&lt;\u20090.05). The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve was 0.94 (6.99\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>, the optimal cut\u2010off value) for <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> measured with <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>0\u20131 and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>2\u20133, 0.89 (9.00\u2009<jats:styled-content style=\"fixed-case\">kPa<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>2\u20133 and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> is a valid and reproducible non\u2010invasive technology in liver stiffness measurement among chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> patients. The stage of liver fibrosis and the grade of necroinflammatory activity are associated with values of <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content> while liver fibrosis is the dominating factor affecting liver stiffness measured by <jats:styled-content style=\"fixed-case\">ElastPQ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12479","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T02:25:01Z","timestamp":1386728701000},"page":"814-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Assessment of liver fibrosis with elastography point quantification technique in chronic hepatitis <scp>B<\/scp> virus patients: A comparison with liver pathological results"],"prefix":"10.1111","volume":"29","author":[{"given":"Jiao\u2010jiao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital, Fudan 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