{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:03:17Z","timestamp":1790240597338,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital, Taiwan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Simethicone and\n N<\/jats:styled-content>\n \u2010acetylcysteine have been widely used in improving endoscopic visibility. However, the optimal dose, volume, and dosing time for the premedication regimen are still unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n Our aim was to assess the efficacy of premedication in improving endoscopic visibility and determine the contributions of dose, volume, and premedication time.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 1849 patients were prospectively treated in three groups: group\n A<\/jats:styled-content>\n : 100\u2010mg simethicone suspension in 5\u2009\n mL<\/jats:styled-content>\n water; group\n B<\/jats:styled-content>\n : 100\u2010mg simethicone suspension in 100\u2009\n mL<\/jats:styled-content>\n water; and group\n C<\/jats:styled-content>\n : 100\u2010mg simethicone suspension in 100\u2009\n mL<\/jats:styled-content>\n water containing 200\u2009mg\n N<\/jats:styled-content>\n \u2010acetylcysteine. Mucosa visibility was assessed at seven sites of upper gastrointestinal tract. The sum of scores was considered as total mucosal visibility score (\n TMVS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The upper body of stomach had the worst visibility score for all groups.\n TMVS<\/jats:styled-content>\n of groups\n B<\/jats:styled-content>\n and\n C<\/jats:styled-content>\n were significantly lower than those of group\n A<\/jats:styled-content>\n . Group\n C<\/jats:styled-content>\n had a significantly fewer patients requiring endoscopic flushing than groups\n A<\/jats:styled-content>\n and\n B<\/jats:styled-content>\n . The\n TMVS<\/jats:styled-content>\n for groups\n B<\/jats:styled-content>\n and\n C<\/jats:styled-content>\n were significantly lower than for group\n A<\/jats:styled-content>\n within 30\u2009min of beginning premedication. Beyond 30\u2009min of premedication, there was no significant difference in the\n TMVS<\/jats:styled-content>\n among groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Premedication using 100\u2009mg simethicone in 100\u2009\n mL<\/jats:styled-content>\n of water improves endoscopic visibility. Addition of\n N<\/jats:styled-content>\n \u2010acetylcysteine to simethicone in 100\u2009\n mL<\/jats:styled-content>\n of water reduces the need for endoscopic flushing. For patients unable to tolerate a large fluid volume, a 5\u2010\n mL<\/jats:styled-content>\n simethicone suspension administered more than 30\u2009min prior to upper endoscopy is suggested.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12487","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T21:25:12Z","timestamp":1386710712000},"page":"769-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Efficacy of simethicone and\n N<\/scp>\n \u2010acetylcysteine as premedication in improving visibility during upper endoscopy"],"prefix":"10.1111","volume":"29","author":[{"given":"Wei\u2010Kuo","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Kung","family":"Yeh","sequence":"additional","affiliation":[{"name":"National Defense Medical Center School of Pharmacy Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuang\u2010Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"National Defense Medical Center School of Pharmacy Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Kuan","family":"Hu","sequence":"additional","affiliation":[{"name":"National Defense Medical Center School of Pharmacy Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00676.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.05.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967046"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/484532"},{"key":"e_1_2_7_6_1","first-page":"892","article-title":"The role of liquid simethicone in enhancing endoscopic visibility prior to esophagogastroduodenoscopy: a prospective, randomized, double\u2010blinded, placebo\u2010controlled trial","volume":"93","author":"Keeratichananont S","year":"2010","journal-title":"J. Med. Assoc. Thai."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i3.444"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i37.4213"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010479"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550140311"},{"key":"e_1_2_7_11_1","first-page":"264","article-title":"Effectiveness of preprocedure simethicone drink in improving visibility during esophagogastroduodenoscopy: a double\u2010blind, randomized study","volume":"15","author":"Banerjee B","year":"1992","journal-title":"J. Clin. Gastroenterol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(78)73542-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182758944"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903483643"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2012.45.2.161"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.08.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7075.162"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000228099.04702.39"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1951.sp004562"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(98)70223-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33220"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16b12.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.749509"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510110205"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01582.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70825-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2012.45.2.113"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12487","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:46:54Z","timestamp":1696474014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/jgh.12487"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12487","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]},"assertion":[{"value":"2013-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}