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Depending on the primary site, angiosarcomas have distinct prognosis. Primary hepatic angiosarcomas (<jats:styled-content style=\"fixed-case\">PHA<\/jats:styled-content>s) are much rare tumors, with worse prognosis compared with other angiosarcomas. <jats:styled-content style=\"fixed-case\">PHA<\/jats:styled-content> is reported to be associated with vinyl chloride, but the majority of patients were still with unknown etiology. As <jats:styled-content style=\"fixed-case\">PHA<\/jats:styled-content> lacks specific symptoms, signs, or images, pathological diagnosis is necessary. The review summarizes 25 articles published from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2000 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012, including 64 cases of <jats:styled-content style=\"fixed-case\">PHA<\/jats:styled-content> with detailed information. Survival curves are estimated using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier method by <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> 21.0. We find that the median survival time is 5 months; local excision alone or combination with adjuvant therapy is the optimal choice, with median survival time of 17 months. In addition, liver transplant is abandoned for high recurrence rate; emergent transcatheter arterial embolization is thought to be an efficient method for controlling intra\u2010abdominal bleeding; and transcatheter arterial chemoembolization and chemotherapy may be helpful in improving survival.<\/jats:p>","DOI":"10.1111\/jgh.12506","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T11:11:21Z","timestamp":1388142681000},"page":"906-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Primary hepatic angiosarcoma and potential treatment options"],"prefix":"10.1111","volume":"29","author":[{"given":"Ya\u2010wen","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010zhen","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010jiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run\u2010mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010bao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center of Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181dbb75a"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm381"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92515-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2223010877"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810201)47:3<466::AID-CNCR2820470307>3.0.CO;2-F"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108793"},{"key":"e_1_2_10_9_1","first-page":"150","article-title":"Angiosarcoma of liver in the manufacture of polyvinyl chloride","volume":"16","author":"Creech JJ","year":"1974","journal-title":"J. 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