{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:53:36Z","timestamp":1779105216141,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Government","award":["NRF-2012R1A1B5002680"],"award-info":[{"award-number":["NRF-2012R1A1B5002680"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Clinical outcomes of H<\/jats:styled-content>elicobacter pylori<\/jats:italic> (HP<\/jats:styled-content><\/jats:italic>) infection have been shown to be dependent on the variability of virulence factors. The aim of this study was to evaluate the prevalence of each virulence factor and the association between polymorphisms of the virulence factors of HP<\/jats:styled-content><\/jats:italic>, and the clinical outcome of gastroduodenal diseases in S<\/jats:styled-content>outh K<\/jats:styled-content>orea.<\/jats:p><\/jats:sec>Methods<\/jats:title>Four hundred one HP<\/jats:styled-content><\/jats:italic> colonies were analyzed (75 colonies from 45 controls; 71 colonies from 39 benign gastric ulcer [BGU<\/jats:styled-content>] patients; 102 colonies from 54 duodenal ulcer [DU<\/jats:styled-content>] patients; 121 colonies from 77 stomach cancer patients; and 32 colonies from 25 dysplasia patients). Polymerase chain reaction amplifications for vacA<\/jats:italic><\/jats:styled-content>, cagA<\/jats:italic><\/jats:styled-content>, iceA<\/jats:italic><\/jats:styled-content>, oipA<\/jats:italic><\/jats:styled-content>, and dupA<\/jats:italic><\/jats:styled-content> were performed using DNA<\/jats:styled-content> extract from HP<\/jats:styled-content><\/jats:italic> isolates cultured from mucosal biopsy specimens. dupA<\/jats:italic><\/jats:styled-content> was regarded as positive when all of jph0718, jph0719, and dupA<\/jats:styled-content> were positive.<\/jats:p><\/jats:sec>Results<\/jats:title>Most colonies were composed of vacA<\/jats:italic><\/jats:styled-content> s1 (100.0%), i1 (100.0%) and m1 (92.9%), cagA<\/jats:italic><\/jats:styled-content>\u2010positive (87.2%), iceA<\/jats:italic><\/jats:styled-content>1 (95.8%), oipA<\/jats:italic><\/jats:styled-content>\u2010positive (91.2%), and dupA<\/jats:italic><\/jats:styled-content>\u2010negative (52.0%) genotypes. dupA<\/jats:italic><\/jats:styled-content> was more frequently expressed in BGU<\/jats:styled-content> (81.3%), DU<\/jats:styled-content> (74.7%), and dysplasia (41.7%) than control (16.7%) (P<\/jats:italic>\u2009<\u20090.001). Infection by dupA<\/jats:italic><\/jats:styled-content>\u2010positive HP<\/jats:styled-content><\/jats:italic> showed an increased risk of BGU<\/jats:styled-content> (odds ratio 33.06, 95% confidence interval 11.91\u201391.79) and DU<\/jats:styled-content> (odds ratio 15.60, 95% confidence interval 6.49\u201337.49).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HP<\/jats:styled-content><\/jats:italic> infection in S<\/jats:styled-content>outh K<\/jats:styled-content>oreans appears to be closely related to highly virulent strains (vacA<\/jats:italic><\/jats:styled-content> s1\/i1\/m1, cagA<\/jats:italic><\/jats:styled-content>(+), iceA<\/jats:italic><\/jats:styled-content>1(+), and oipA<\/jats:italic><\/jats:styled-content>(+)), except dupA<\/jats:italic><\/jats:styled-content>. dupA<\/jats:italic><\/jats:styled-content> has an intimate association with the development of peptic ulcer diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12509","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T11:12:28Z","timestamp":1388142748000},"page":"984-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Association of polymorphisms in virulence factor of H<\/scp>elicobacter pylori<\/i> and gastroduodenal diseases in S<\/scp>outh K<\/scp>orea"],"prefix":"10.1111","volume":"29","author":[{"given":"Ji Yeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoung Hee","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyung","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Gastroenterology Healthcare System Gangnam Center Seoul National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Mogg","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung 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