{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:55:39Z","timestamp":1790776539825,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171526"],"award-info":[{"award-number":["81171526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"2010 subject of the Third Military Medical University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study was designed to demonstrate the safety and efficacy of esomeprazole combined with flupentixol\/melitracen for the treatment of gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) patients with emotional disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred eighty\u2010nine <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients with emotional disorders were divided randomly into two groups: group 1 received esomeprazole only (monotherapy) and group 2 received esomeprazole and flupentixol\/melitracen (combination therapy). The patients' <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> questionnaire (<jats:styled-content style=\"fixed-case\">GerdQ<\/jats:styled-content>) and hospital anxiety and depression (<jats:styled-content style=\"fixed-case\">HAD<\/jats:styled-content>) scores were obtained before and after treatment. Changes in the scores, rates of symptom remission, and adverse effects were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 2 weeks of treatment, the average decrease in <jats:styled-content style=\"fixed-case\">GerdQ<\/jats:styled-content> score in the combination group (4.04\u2009\u00b1\u20092.34) was significantly greater than that in the monotherapy group (3.34\u2009\u00b1\u20092.74; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Significant differences between the two groups were also found for changes in <jats:styled-content style=\"fixed-case\">HAD<\/jats:styled-content> anxiety scores (5.45\u2009\u00b1\u20092.41 <jats:italic>vs<\/jats:italic> 3.34\u2009\u00b1\u20092.43, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), depression scores (5.47\u2009\u00b1\u20092.47 <jats:italic>vs<\/jats:italic> 3.00\u2009\u00b1\u20093.28, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and anxiety\u2010depression scores (5.20\u2009\u00b1\u20092.71 <jats:italic>vs<\/jats:italic> 3.60\u2009\u00b1\u20092.56, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The remission of symptoms (eructation, abdominal pain, anorexia, and other accompanying symptoms) in the combination group was significantly better than that in the monotherapy group, and no significant difference in the incidence of adverse events was observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination therapy has better efficacy than the monotherapy in improving the symptoms of gastroesophageal reflux in patients with emotional disorders. In addition, this combination treatment is safe, with a low incidence of adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12552","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T11:05:40Z","timestamp":1392980740000},"page":"1200-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of esomeprazole with flupentixol\/melitracen in treating gastroesophageal reflux disease patients with emotional disorders"],"prefix":"10.1111","volume":"29","author":[{"given":"Yan\u2010Yan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian\u2010Chun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Southwest Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hui","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Daping Hospital, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.09.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.504"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2006.10.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814177"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-161"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12125"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.044"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(02)00146-4"},{"key":"e_1_2_6_12_1","first-page":"557","article-title":"New pharmacologic approaches in gastroesophageal reflux disease","volume":"4","author":"Armstrong D","year":"2010","journal-title":"Thorac. 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