{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:44:39Z","timestamp":1696239879237},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Peliosis hepatis\u2010like blood\u2010filled cavities are frequently observed in hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>). Peliotic change (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) is commonly seen in moderately differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s and rarely in well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s. We conducted clinicopathological analysis of well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PHCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1225 patients underwent hepatectomy at <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>urume <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital between 1992 and 2010. Of these, 101 cases were diagnosed as well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. Immunohistochemical double staining of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 and \u03b1 smooth muscle actin was performed to examine the number and diameter of arterial blood vessels and drainage veins around tumors. We compared the clinical manifestations, histopathological features, and imaging findings of these cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven cases of 101 well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCCs<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>. Almost of <jats:styled-content style=\"fixed-case\">PHCCs<\/jats:styled-content> were macroscopically classified as the simple nodular type with a fibrous capsule, and microscopically showed thin trabecular arrangement of tumor cells and extensive dilated sinusoid\u2010like structures filled with red blood cells. The number of arteries inside the tumor was significantly higher in <jats:styled-content style=\"fixed-case\">PHCC<\/jats:styled-content>s than in the simple nodular type of well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s without <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>. Furthermore, no significant differences were observed in the ratio of the number of irregularly shaped drainage veins around the tumor to the tumor diameter. Imaging revealed that most of the tumors had capsule\u2010like structures and showed prolonged enhancement in the delayed phase of dynamic study of imagings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> is unusually observed in well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and the size of <jats:styled-content style=\"fixed-case\">PHCC<\/jats:styled-content> was larger than that of well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> and most are detected as a hypervascular tumor on images.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12565","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:37:37Z","timestamp":1393263457000},"page":"1494-1499","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathologic analysis of the simple nodular type of well\u2010differentiated hepatocellular carcinoma with extensive peliotic change"],"prefix":"10.1111","volume":"29","author":[{"given":"Yoriko","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"},{"name":"Department of Surgery Kurume University School of Medicine  Kurume Japan"},{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Clinical laboratory Medicine Kurume University Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Kumabe","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kage","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinoshita","family":"Hisafumi","sequence":"additional","affiliation":[{"name":"Department of Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0167"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ol_00000003","article-title":"Clinicopathological study of hepatocellular carcinoma with peliotic change","volume":"1","author":"Fujimoto M","year":"2009","journal-title":"Oncol Lett."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-008-0035-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2007.8.1.64"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2412051243"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009730903262118"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471576"},{"key":"e_1_2_5_9_1","first-page":"149","article-title":"A rare clinical entity misdiagnosed as a tumor: peliosis hepatis","volume":"13","author":"Atila K","year":"2007","journal-title":"Ulus. 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