{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:56:13Z","timestamp":1780095373233,"version":"3.54.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The role of clinical symptoms, transabdominal ultrasound scan (USS<\/jats:styled-content>), and liver function tests (LFTs<\/jats:styled-content>) in evaluating common bile duct (CBD<\/jats:styled-content>) stones in patients suspected to have pancreatobiliary disease has been studied. However, it is unclear whether these predictive models are useful in different age cohorts. The aim of this study is to investigate the clinical presentations from different age cohorts with and without CBD<\/jats:styled-content> stones.<\/jats:p><\/jats:sec>Methods<\/jats:title>Four hundred and forty\u2010three patients with pancreatobiliary diseases were divided into cohorts according to decades as follows: young (Y<\/jats:styled-content>, 18\u201364 years old, n<\/jats:italic>\u2009=\u2009143), young\u2010old (YO<\/jats:styled-content>, 65\u201374 years old, n<\/jats:italic>\u2009=\u2009168), old\u2010old (OO<\/jats:styled-content>, 75\u201384 years old, n<\/jats:italic>\u2009=\u200997), and very old (VO<\/jats:styled-content>, \u2265\u200985 years old, n<\/jats:italic>\u2009=\u200935). The clinical symptoms, LFT<\/jats:styled-content>s, and USS<\/jats:styled-content> findings were demonstrated and compared among patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Y<\/jats:styled-content>\u2010 and YO<\/jats:styled-content>\u2010group patients were more likely to develop symptoms such as biliary colic in the presence of CBD<\/jats:styled-content> stones. The proportion of abnormal serum aspartate aminotransferase and alanine aminotransferase were significantly greater in Y<\/jats:styled-content>\u2010, YO<\/jats:styled-content>\u2010, and OO<\/jats:styled-content>\u2010group patients with than in those without CBD<\/jats:styled-content> stones. Sensitivity of USS<\/jats:styled-content> for CBD<\/jats:styled-content> stones in Y<\/jats:styled-content>: 0.15; YO<\/jats:styled-content>: 0.45; OO<\/jats:styled-content>: 0.57; and VO<\/jats:styled-content>: 0.68. Accuracy of USS<\/jats:styled-content> for detected CBD<\/jats:styled-content> stone in Y<\/jats:styled-content>: 48%; YO<\/jats:styled-content>: 62.5%; OO<\/jats:styled-content>: 70.1%; and VO<\/jats:styled-content>: 71.4%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Combined evaluation of clinical symptoms, biochemical and USS<\/jats:styled-content> findings may help predict the presence of CBD<\/jats:styled-content> stones. In Y<\/jats:styled-content>, YO<\/jats:styled-content>, and OO<\/jats:styled-content> patients with CBD<\/jats:styled-content> stones, the incidences of abnormal LFTs<\/jats:styled-content> were higher. The sensitivity and accuracy of USS<\/jats:styled-content> in detecting CBD<\/jats:styled-content> stones were increased according to age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12581","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T11:21:51Z","timestamp":1394796111000},"page":"1614-1619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical presentations of patients from different age cohorts with biliary tract stone diseases"],"prefix":"10.1111","volume":"29","author":[{"given":"Kuang\u2010Chun","family":"Hu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital New Taipei Taiwan"},{"name":"Healthy Evaluation Center Mackay Memorial Hospital New Taipei Taiwan"},{"name":"Mackay Junior College of Medicine, Nursing and Management New Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine 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