{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:51Z","timestamp":1787015451087,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2011-0030001"],"award-info":[{"award-number":["2011-0030001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n The association of various genetic polymorphisms with functional dyspepsia (\n FD<\/jats:styled-content>\n ) has been suggested, but the results were still controversial. The aim of the present study was to assess the association of\n \n GNB<\/jats:styled-content>\n 3\n <\/jats:italic>\n 825\n C<\/jats:styled-content>\n >\n T<\/jats:styled-content>\n ,\n \n SLC<\/jats:styled-content>\n 6\n A<\/jats:styled-content>\n 4\n <\/jats:italic>\n 5\u2010\n HTTLPR<\/jats:styled-content>\n ,\n \n ADRA<\/jats:styled-content>\n 2\n A<\/jats:styled-content>\n \u2010\n <\/jats:italic>\n 1291\n C<\/jats:styled-content>\n >\n G<\/jats:styled-content>\n ,\n \n CCK<\/jats:styled-content>\n \u20101\n R<\/jats:styled-content>\n <\/jats:italic>\n intron 779\n T<\/jats:styled-content>\n >\n C<\/jats:styled-content>\n , and\n \n TRPV<\/jats:styled-content>\n 1\n <\/jats:italic>\n 945\n G<\/jats:styled-content>\n >\n C<\/jats:styled-content>\n polymorphisms with\n FD<\/jats:styled-content>\n based on\n R<\/jats:styled-content>\n ome III criteria in\n K<\/jats:styled-content>\n orea.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Study subjects were prospectively recruited from visitors to\n S<\/jats:styled-content>\n eoul\n N<\/jats:styled-content>\n ational\n U<\/jats:styled-content>\n niversity\n B<\/jats:styled-content>\n undang\n H<\/jats:styled-content>\n ospital between 2009 and 2012. One hundred and twelve\n FD<\/jats:styled-content>\n patients and 269 controls were enrolled.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In\n \n SLC<\/jats:styled-content>\n 6\n A<\/jats:styled-content>\n 4\n <\/jats:italic>\n 5\u2010\n HTTLPR<\/jats:styled-content>\n polymorphism, the frequency of\n S<\/jats:styled-content>\n \/\n S<\/jats:styled-content>\n genotype was significantly lower than that of\n L<\/jats:styled-content>\n \/\n L<\/jats:styled-content>\n \u2009+\u2009\n L<\/jats:styled-content>\n \/\n S<\/jats:styled-content>\n genotype in\n FD<\/jats:styled-content>\n compared to controls (\n P<\/jats:italic>\n \u2009<\u20090.05). After stratification according to\n Helicobacter pylori<\/jats:italic>\n infection, the\n S<\/jats:styled-content>\n \/\n S<\/jats:styled-content>\n genotype was significantly associated with\n \n H<\/jats:styled-content>\n .\u2009pylori\n <\/jats:italic>\n \u2010positive epigastric pain syndrome (\n EPS<\/jats:styled-content>\n ) patients (adjusted odds ratio (\n OR<\/jats:styled-content>\n ) 0.46; 95% confidence interval (\n CI<\/jats:styled-content>\n ) 0.22\u20130.99;\n P<\/jats:italic>\n \u2009=\u20090.048). In\n \n TRPV<\/jats:styled-content>\n 1\n <\/jats:italic>\n 945\n G<\/jats:styled-content>\n >\n C<\/jats:styled-content>\n polymorphism, the frequency of\n C<\/jats:styled-content>\n \/\n C<\/jats:styled-content>\n genotype was lower in\n FD<\/jats:styled-content>\n compared to controls (\n P<\/jats:italic>\n \u2009=\u20090.057). The\n C<\/jats:styled-content>\n carrier and\n C<\/jats:styled-content>\n \/\n C<\/jats:styled-content>\n genotype was significantly associated with postprandial distress syndrome (\n PDS<\/jats:styled-content>\n ) and\n EPS<\/jats:styled-content>\n , respectively (adjusted\n OR<\/jats:styled-content>\n 0.47 and 0.43; 95%\n CI<\/jats:styled-content>\n 0.25\u20130.90 and 0.20\u20130.93;\n P<\/jats:italic>\n \u2009=\u20090.021 and 0.033). After stratification, the significant associations remained in\n \n H<\/jats:styled-content>\n .\u2009pylori\n <\/jats:italic>\n \u2010positive\n PDS<\/jats:styled-content>\n and\n EPS<\/jats:styled-content>\n patients (adjusted\n OR<\/jats:styled-content>\n 0.37 and 0.28; 95%\n CI<\/jats:styled-content>\n 0.16\u20130.88 and 0.09\u20130.85;\n P<\/jats:italic>\n \u2009=\u20090.024 and 0.025).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The genetic polymorphism of\n \n SLC<\/jats:styled-content>\n 6\n A<\/jats:styled-content>\n 4\n <\/jats:italic>\n 5\u2010\n HTTLPR<\/jats:styled-content>\n and\n \n TRPV<\/jats:styled-content>\n 1\n <\/jats:italic>\n 945G>\n C<\/jats:styled-content>\n could be one of the pathophysiological factors of\n FD<\/jats:styled-content>\n , especially in the case of\n \n H<\/jats:styled-content>\n .\u2009pylori\n <\/jats:italic>\n \u2010positive patients in\n K<\/jats:styled-content>\n orea.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12596","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T02:50:14Z","timestamp":1397184614000},"page":"1770-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The association of\n \n SLC<\/scp>\n 6\n A<\/scp>\n 4\n <\/i>\n 5\u2010\n HTTLPR<\/scp>\n and\n \n TRPV<\/scp>\n 1\n <\/i>\n 945\n G<\/scp>\n >\n C<\/scp>\n with functional dyspepsia in\n K<\/scp>\n orea"],"prefix":"10.1111","volume":"29","author":[{"given":"Sung Wook","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Gyeonggi\u2010do Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Kyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ewha Womans University School of Medicine Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heebal","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences Seoul National University Seoul Gyeonggi\u2010do Korea"},{"name":"Interdisciplinary Program in Bioinformatics Seoul National University Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaemin","family":"Kim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Bioinformatics Seoul National University Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Chae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J. 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