{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:06:37Z","timestamp":1780095997371,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Family Medicine, National Cheng Kung University Hospital, Taiwan","award":["NCKUHFM-101-002"],"award-info":[{"award-number":["NCKUHFM-101-002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds and Aim<\/jats:title><jats:p>The association between <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection and diabetes was inconsistent in previous studies. Moreover, there are no studies on the relationship between <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection and prediabetes in the literature. The aim of this study is thus to assess the association of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter<\/jats:italic> infection, diagnosed by pathology from gastric biopsy, with diabetes and prediabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 1285 subjects aged 19\u201385 who underwent esophagogastroduodenoscopy and gastric biopsy during health examinations at <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>heng <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ung <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital from 2000 to 2009. Subjects were divided into three groups, including normal glucose tolerance, prediabetes, and diabetes. Diabetes and prediabetes were assessed according to the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iabetes <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssociation diagnostic criteria. Gastric <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter<\/jats:italic> infection was an independent variable. Chi\u2010square tests, analysis of variance, and multinomial logistic regression models were used to analyze the effects of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter<\/jats:italic> infection on the risk of diabetes and prediabetes while controlling for age, lifestyle, pathological conditions, and laboratory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in the prevalence of gastric <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter<\/jats:italic> infection among the three groups. The results of multivariate analysis showed that age, obesity, family history of diabetes, hypertension, and hypertriglyceridemia were significantly related to both prediabetes and diabetes. <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection was positively associated with diabetes (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.01\u20132.01), but not prediabetes (OR 1.02, 95% CI 0.77\u20131.36), in addition to male gender, education level (\u2264\u20099 <jats:italic>vs<\/jats:italic> &gt;\u200912 years), pre\u2010hypertension, and low high\u2010density lipoprotein cholesterol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection is associated with diabetes, but not prediabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12617","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T12:11:15Z","timestamp":1397477475000},"page":"1794-1799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Gastric <scp>H<\/scp>elicobacter pylori infection associated with risk of diabetes mellitus, but not prediabetes"],"prefix":"10.1111","volume":"29","author":[{"given":"Gi\u2010Hua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Family Medicine National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Shang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine National Cheng Kung University Hospital  Tainan Taiwan"},{"name":"Department of Family Medicine College of Medicine National Cheng Kung University  Tainan 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