{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:04:21Z","timestamp":1790424261723,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Transarterial radioembolization with yttrium\u201090 microspheres is one treatment option for inoperable hepatocellular carcinoma. We compared the survival in a cohort of patients receiving radioembolization or no radioembolization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 46 patients referred for radioembolization was retrospectively reviewed. The patient, tumor characteristics, and the survival were compared in the two groups. The independent predictors for survival were studied with multivariate analysis. The side\u2010effects and the complication of radioembolization\u2010induced liver disease was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u2002Thirty patients received radioembolization; 16 patients did not. The two groups did not differ in the mean age, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh classes, Barcelona Clinic of Liver Cancer (<jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content>) stages, tumor types, sum of diameter of the two biggest tumors, and extent of portal vein invasion. Those with <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> tumor, with portal vein thrombus, or with less than three nodules had significantly longer survival after radioembolization. There was a trend of longer survival in patients with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh A liver function, or with <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> tumor after radioembolization. The median survival was more than 31.9 months, 14.5 months, and 5.2 months in patients with <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> tumors. The independent predictors for longer survival were <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh class, tumor diameter sum, <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> stage, and receiving radioembolization. Grade 2 irradiation\u2010induced gastritis occurred in three patients (10%). Radioembolization\u2010induced liver disease occurred in four patients (13%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radioembolization may prolong survival for patients with inoperable hepatocellular carcinoma. Radioembolization\u2010induced liver disease occurred and should be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12621","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T09:55:24Z","timestamp":1397642124000},"page":"1897-1904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Survival benefit of radioembolization for inoperable hepatocellular carcinoma using yttrium\u201090 microspheres"],"prefix":"10.1111","volume":"29","author":[{"given":"Philip Chong\u2010Hei","family":"Kwok","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Queen Elizabeth Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong Chuen","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Queen Elizabeth Hospital  Hong 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