{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:24:31Z","timestamp":1760865871800,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["23790822"],"award-info":[{"award-number":["23790822"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ishibashi Foundation for the Promotion of Science"},{"name":"Ministry of Health, Labour and Welfare of Japan"},{"name":"Medical care education research foundation"},{"DOI":"10.13039\/501100007206","name":"Kaibara Morikazu Medical Science Promotion Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007206","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Terumo Life Science Foundation"},{"name":"Clinical Medicine Promotion Foundation"},{"DOI":"10.13039\/501100008890","name":"Viral Hepatitis Research Foundation of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008890","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MEXT-Supported Program for the Strategic Research Foundation at Private Universities"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Preclinical studies in rodent models of chronic liver fibrosis have shown that transplantation of peripheral blood (PB<\/jats:styled-content>) CD<\/jats:styled-content>34+<\/jats:sup> cells leads to hepatic regeneration and a reduction of liver fibrosis by suppressing hepatic stellate cell activity and increasing matrix metalloproteinase activity. The aim of this study was to examine the safety and clinical efficacy of intrahepatic transplantation of autologous granulocyte colony\u2010stimulating factor (G<\/jats:styled-content>\u2010CSF<\/jats:styled-content>)\u2010mobilized PB<\/jats:styled-content>\u2010CD<\/jats:styled-content>34+<\/jats:sup> cells in patients with decompensated liver cirrhosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>PB<\/jats:styled-content>\u2010CD<\/jats:styled-content>34+<\/jats:sup> cells were isolated from G<\/jats:styled-content>\u2010CSF<\/jats:styled-content>\u2010mobilized apheresis products. Ten patients were treated with G<\/jats:styled-content>\u2010CSF<\/jats:styled-content>\u2010mobilized PB<\/jats:styled-content>\u2010CD<\/jats:styled-content>34+<\/jats:sup> cells (treatment group) and seven patients were treated with standard medical therapy. For mobilization, patients in the treatment group received subcutaneous injections of 10\u2009\u03bcg G<\/jats:styled-content>\u2010CSF<\/jats:styled-content>\/kg\/day for 5 days. The cells were then injected at three different doses (5\u2009\u00d7\u2009105<\/jats:sup>, 1\u2009\u00d7\u2009106<\/jats:sup> and 2\u2009\u00d7\u2009106<\/jats:sup> cells\/kg) through the hepatic artery. Thereafter, all patients were followed up for 24 months.<\/jats:p><\/jats:sec>Results<\/jats:title>G<\/jats:styled-content>\u2010CSF<\/jats:styled-content> treatment and leukapheresis were well tolerated, and no serious adverse events were observed. Patients in the treatment group had a significant but transient splenomegaly. After 24 weeks, serum albumin was significantly increased in patients who had received middle or high doses of CD<\/jats:styled-content>34+<\/jats:sup> cells compared with baseline. Doppler ultrasound showed a significant increase in hepatic blood flow velocity and blood flow volume after CD<\/jats:styled-content>34+<\/jats:sup> cell therapy. The hepatic vein pressure gradient decreased in two patients who received high\u2010dose CD<\/jats:styled-content>34+<\/jats:sup> cells at week 16.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CD<\/jats:styled-content>34+<\/jats:sup> cell therapy is feasible, safe and effective in slowing the decline of hepatic reserve function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12622","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T12:11:31Z","timestamp":1397477491000},"page":"1830-1838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["CD<\/scp>34+<\/sup> cell therapy is safe and effective in slowing the decline of hepatic reserve function in patients with decompensated liver cirrhosis"],"prefix":"10.1111","volume":"29","author":[{"given":"Toru","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Kurume University School 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