{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:24:31Z","timestamp":1760898271821,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>With an increasing burden on overstretched colonoscopy services, a simple risk score for significant pathology in symptomatic patients may aid in the prioritization of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A derivative study of a risk score model for colonic neoplasia (colorectal carcinoma [<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>] and advanced adenoma) and <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> alone was conducted in symptomatic adults referred for an index colonoscopy. The accuracy of the final model was assessed by the area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) of the receiver operating characteristic curve and the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>osmer\u2013<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>emeshow goodness\u2010of\u2010fit statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1013 subjects (mean age 59.9\u2009\u00b1\u200913.7 years, 52.3% females) from a multi\u2010ethnic <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian background (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese 56%, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>alay 20.4%, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndian 21.5%) were recruited. Colonic neoplasia and <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> were identified in 175 (17.3%) and 114 (11.3%) cases, respectively. Risk scores were assigned to individual factors identified in a logistic regression model of both demographic (age, gender, ethnicity, education level, smoking history, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>spirin use) and clinical symptoms (change in bowel habit, bloody stool, weight loss, appetite loss, lethargy). The risk score for each patient was the sum of their individual risk factors. The <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of the risk score for colonic neoplasia and <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> was 0.76 (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>osmer\u2013<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>emeshow goodness\u2010of\u2010fit statistic of <jats:italic>P<\/jats:italic>\u2009=\u20090.745) and 0.83 (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>osmer\u2013<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>emeshow goodness\u2010of\u2010fit statistic of <jats:italic>P<\/jats:italic>\u2009=\u20090.982), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A simple risk score for colonic neoplasia and <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> may be able to prioritize colonoscopy referrals in symptomatic subjects from a multi\u2010ethnic background. A further study to validate this scoring system is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12638","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T10:55:13Z","timestamp":1402311313000},"page":"1890-1896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Development of a risk score to stratify symptomatic adults referred for colonoscopy"],"prefix":"10.1111","volume":"29","author":[{"given":"Chee\u2010Wei","family":"Law","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Rampal","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine Julius Centre University of Malaya Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April C","family":"Roslani","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-0590","authenticated-orcid":false,"given":"Sanjiv","family":"Mahadeva","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2007.00304.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70422-8"},{"key":"e_1_2_5_4_1","first-page":"353","article-title":"Colonoscopy: a review of its yield for cancers and adenomas by indication","volume":"90","author":"Rex DK","year":"1995","journal-title":"Am. 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