{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:02:37Z","timestamp":1787619757323,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Fund of China","award":["81170413"],"award-info":[{"award-number":["81170413"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The epithelial\u2013mesenchymal transition (EMT<\/jats:styled-content>) of hepatocytes is a key step for hepatic fibrosis and cirrhosis. Long\u2010term administration of celecoxib, a selective cyclooxygenase\u20102 (COX<\/jats:styled-content>\u20102) inhibitor, can ameliorate hepatic fibrosis. This research aimed to examine the effect of celecoxib on the EMT<\/jats:styled-content> of hepatocytes during the development of liver cirrhosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cirrhotic liver model of rat was established by peritoneal injection of thiacetamide (TAA<\/jats:styled-content>). Thirty\u2010six rats were randomly assigned to control, TAA<\/jats:styled-content>, and TAA<\/jats:styled-content>\u2009+\u2009celecoxib groups. Hepatic expressions of tumor necrosis factor\u2010\u03b1 (TNF<\/jats:styled-content>\u2010\u03b1), interleukin 6 (IL<\/jats:styled-content>\u20106), COX<\/jats:styled-content>\u20102, prostaglandin E<\/jats:styled-content>2<\/jats:sub> (PGE<\/jats:styled-content>2<\/jats:sub>), matrix metalloproteinase (MMP)\u20102 and \u20109, transforming growth factor\u2010\u03b21 (TGF<\/jats:styled-content>\u2010\u03b21), P<\/jats:styled-content>hospho\u2010S<\/jats:styled-content>mad2\/3, S<\/jats:styled-content>nail1, \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA<\/jats:styled-content>), vimentin, collagen I<\/jats:styled-content>, fibroblast\u2010specific protein (FSP<\/jats:styled-content>\u20101), E<\/jats:styled-content><\/jats:italic>\u2010cadherin and N<\/jats:styled-content><\/jats:italic>\u2010cadherin were quantitated. Hepatic fibrosis was assessed by the visible hepatic fibrotic areas and I<\/jats:styled-content>shak's scoring system.<\/jats:p><\/jats:sec>Results<\/jats:title>Exposed to TAA<\/jats:styled-content> treatment, hepatocytes underwent the process of EMT<\/jats:styled-content> during hepatic fibrosis. Compared with those in TAA<\/jats:styled-content> group, celecoxib significantly downregulated the hepatic expressions of TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u20106, COX<\/jats:styled-content>\u20102, PGE<\/jats:styled-content>2<\/jats:sub>, MMP<\/jats:styled-content>\u20102, MMP<\/jats:styled-content>\u20109, TGF<\/jats:styled-content>\u2010\u03b21, P<\/jats:styled-content>hospho\u2010S<\/jats:styled-content>mad2\/3, S<\/jats:styled-content>nail1, \u03b1\u2010SMA<\/jats:styled-content>, FSP<\/jats:styled-content>\u20101, and vimentin while greatly restoring the levels of E<\/jats:styled-content>\u2010<\/jats:italic>cadherin. The fibrotic areas and collagen I<\/jats:styled-content> levels of TAA<\/jats:styled-content>\u2009+\u2009celecoxib group were much lower than those in TAA<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Celecoxib could ameliorate hepatic fibrosis and cirrhosis in TAA<\/jats:styled-content>\u2010rat model through suppression of the mesenchymal biomarkers in the hepatocytes while restoring the levels of their epithelial biomarkers. The inhibitory effect of celecoxib on the EMT<\/jats:styled-content> of hepatocytes is associated with reduction of intrahepatic inflammation, preservation of normal basement matrix, and inhibition of TGF<\/jats:styled-content>\u2010\u03b21\/S<\/jats:styled-content>mad pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12641","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T10:55:27Z","timestamp":1402311327000},"page":"1932-1942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Celecoxib attenuates hepatic cirrhosis through inhibition of epithelial\u2010to\u2010mesenchymal transition of hepatocytes"],"prefix":"10.1111","volume":"29","author":[{"given":"Shi\u2010Lei","family":"Wen","sequence":"first","affiliation":[{"name":"Regenerative Medicine Research Center West China Hospital Chengdu China"},{"name":"Division of Peptides Related with Human Diseases State Key Laboratory of Biotherapy Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hang","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Peptides Related with Human Diseases State Key Laboratory of Biotherapy Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang\u2010Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Liver Diseases Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Peptides Related with Human Diseases State Key Laboratory of Biotherapy Sichuan University Chengdu China"},{"name":"Department of Gastroenterology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130246"},{"issue":"1","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1186\/1755-1536-5-S1-S26","article-title":"Reversibility of liver fibrosis","volume":"5","author":"Pellicoro A","year":"2012","journal-title":"Fibrogenesis. 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