{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:08:15Z","timestamp":1744178895608,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"crossref","award":["21A113"],"award-info":[{"award-number":["21A113"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The accuracy for predicting virological outcomes of peginterferon\u2010\u03b1 and ribavirin therapy in patients with chronic hepatitis C<\/jats:styled-content> is limited to approximately 80%, even with IL<\/jats:styled-content>28B<\/jats:styled-content><\/jats:italic> genotyping. Our in vitro<\/jats:italic> study revealed that the numbers of (TA<\/jats:styled-content>) dinucleotide repeats [(TA<\/jats:styled-content>)n] of rs72258881, which is located in the promoter region of IL<\/jats:styled-content>28B<\/jats:styled-content><\/jats:italic> gene, might regulate IL<\/jats:styled-content>28B<\/jats:styled-content><\/jats:italic> transcription. We aimed to evaluate the usefulness of these host factors for predicting virological outcomes of this therapy in response\u2010guided clinical settings.<\/jats:p><\/jats:sec>Methods<\/jats:title>A nationwide, multi\u2010center prospective study in J<\/jats:styled-content>apan determined IL<\/jats:styled-content>28B<\/jats:styled-content><\/jats:italic> (rs8099917) genotype, (TA<\/jats:styled-content>)n of rs72258881, and amino acid substitutions of hepatitis C<\/jats:styled-content> virus and used these for multivariate analysis together with other parameters at pretreatment.<\/jats:p><\/jats:sec>Results<\/jats:title>After enrolling 215 patients with genotype 1 and high viral load from 23 hospitals between O<\/jats:styled-content>ctober 2009 and F<\/jats:styled-content>ebruary 2011, intent\u2010to\u2010treat analysis identified 202 patients in whom the final virological outcomes could be determined. Non\u2010virological response by non\u2010TT<\/jats:styled-content> genotype was predicted with 79.7% accuracy. When combined with the (TA<\/jats:styled-content>)n, the incidences of virological response tended to be higher in the longer (TA<\/jats:styled-content>)n group, regardless of rs8099917 genotype. Multivariate logistic regression analysis revealed that rs8099917 non\u2010TT<\/jats:styled-content> genotype (P<\/jats:italic>\u2009<\u20090.001), shorter (TA<\/jats:styled-content>)n (P<\/jats:italic>\u2009=\u20090.011), mutation of amino acid 70 in the virus core region (P<\/jats:italic>\u2009=\u20090.029), and lower levels of serum albumin (P<\/jats:italic>\u2009=\u20090.036) were independently associated with non\u2010virological response.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IL<\/jats:styled-content>28B<\/jats:styled-content><\/jats:italic> genotype and (TA<\/jats:styled-content>)n of rs72258881 may independently affect virological outcomes of peginterferon\u2010\u03b1 and ribavirin as host factors, even in response\u2010guided therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12646","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T10:55:37Z","timestamp":1402311337000},"page":"1996-2005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pretreatment prediction of the outcome of response\u2010guided peginterferon\u2010\u03b1 and ribavirin therapy for chronic hepatitis C<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"Naohiko","family":"Masaki","sequence":"first","affiliation":[{"name":"The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine Chiba 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