{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:48:54Z","timestamp":1792435734628,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Takeda Pharmaceuticals (Asia Pacific) Pte Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Data on patient satisfaction with proton pump inhibitor (PPI<\/jats:styled-content>) therapy for gastroesophageal reflux disease (GERD<\/jats:styled-content>) are scarce in Asia. The perspectives of Asian patients with GERD<\/jats:styled-content> and their satisfaction with PPI<\/jats:styled-content> therapy were investigated.<\/jats:p><\/jats:sec>Methods<\/jats:title>The GERD<\/jats:styled-content> in A<\/jats:styled-content>sia P<\/jats:styled-content>acific S<\/jats:styled-content>urvey (GAPS<\/jats:styled-content>) was conducted from D<\/jats:styled-content>ecember 2011 to M<\/jats:styled-content>arch 2012. Patients aged 21\u201355 years with self\u2010reported doctor\u2010diagnosed GERD<\/jats:styled-content>, who had experienced symptoms in the previous 12 months, and were currently taking PPIs<\/jats:styled-content> were enrolled. After a pilot study, a questionnaire was completed by respondents from six Asian countries during face\u2010to\u2010face interviews.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 450 patients with GERD<\/jats:styled-content> participated in the GAPS<\/jats:styled-content>. Although the respondents generally complied with treatment, response to therapy was only partially successful. Most respondents indicated that PPIs<\/jats:styled-content> eliminated pain (72%), took effect within 30\u2009min (76%), provided sustained relief (73%), and provided nocturnal relief (77%). However, 45% of respondents reported limited improvement in nocturnal symptoms, and 49% continued to take adjunctive therapy to manage their symptoms. After treatment, respondent's \u201cwell\u2010being\u201d had improved. However, GERD<\/jats:styled-content> still had a negative impact on well\u2010being for 76% of respondents after treatment, compared with 94% before treatment.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A<\/jats:styled-content>sian patients reported a negative impact of GERD<\/jats:styled-content> on their daily lives. Many respondents continued to experience symptoms despite reporting good compliance with PPI<\/jats:styled-content> therapy, emphasizing the shortcomings of currently available therapy for GERD<\/jats:styled-content>. This survey is the first to highlight A<\/jats:styled-content>sian patients' perspectives of GERD<\/jats:styled-content> and PPI<\/jats:styled-content> therapy, and provides a platform for further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12655","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T02:48:20Z","timestamp":1404355700000},"page":"1969-1975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Unmet treatment needs of gastroesophageal reflux disease in A<\/scp>sia: Gastroesophageal reflux disease in A<\/scp>sia P<\/scp>acific S<\/scp>urvey"],"prefix":"10.1111","volume":"29","author":[{"given":"Khean Lee","family":"Goh","sequence":"first","affiliation":[{"name":"Department of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Gyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ping I","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon Jai","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varocha","family":"Mahachai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Chulalongkorn University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udom","family":"Kachintorn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Leelakusolvong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Aziz","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Indonesia Depok Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin CY","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Tang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo","family":"Chu","sequence":"additional","affiliation":[{"name":"Medical Affairs Takeda Pharmaceuticals (Asia Pacific) Pte Ltd Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Shetty","sequence":"additional","affiliation":[{"name":"Medical Affairs Takeda Pharmaceuticals (Asia Pacific) Pte Ltd Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-0028","authenticated-orcid":false,"given":"Joseph C","family":"Bocobo","sequence":"additional","affiliation":[{"name":"St. Luke's College of Medicine\u2014William H. Quasha Memorial Quezon City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchor M","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery University of Santo Tomas Hospital Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw Town","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine Fu Jen Catholic University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05249.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.45"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_7_5_1","unstructured":"American Gastroenterological Society 2011.New nationwide survey identifies need for increased dialogue between gastroesophageal reflux disease or frequent heartburn sufferers and health care providers; Available from:www.gastro.org\/news\/articles\/2011\/03\/23\/new\u2010nationwide\u2010survey\u2010identifies\u2010need\u2010for\u2010increased\u2010dialogue\u2010between\u2010gastroesophageal\u2010reflux\u2010disease\u2010or\u2010frequent\u2010heartburn\u2010sufferers\u2010and\u2010health\u2010care\u2010providers. 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