{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:30:01Z","timestamp":1773009001311,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gangwon branch, the Korean Society of Gastrointestinal Endoscopy","award":["KSGE_KW_06"],"award-info":[{"award-number":["KSGE_KW_06"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The aim of this study was to assess the therapeutic effect of mosapride in patients with functional dyspepsia (FD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Randomized controlled trials (RCT<\/jats:styled-content>s) of mosapride for the treatment of FD<\/jats:styled-content> performed between 2002 and 2013 were identified from databases. Symptom response rates were extracted and analyzed using risk ratios (RR<\/jats:styled-content>s). A random effect model was applied based on H<\/jats:styled-content>iggins I<\/jats:italic>2<\/jats:sup> tests. Publication bias was evaluated using a funnel plot, E<\/jats:styled-content>gger's test, trim and fill, and the rank correlation test.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 13 RCT<\/jats:styled-content>s, which included 1091 mosapride\u2010treated patients and 1129 control patients (on placebo or other drugs), were identified and analyzed. Overall, mosapride showed an RR<\/jats:styled-content> of 0.999 (95% confidence interval [CI<\/jats:styled-content>]: 0.869\u20131.150, P<\/jats:italic>\u2009=\u20090.992) for improving global efficacy or symptom\u2010based scores. In a sensitivity analysis of the high\u2010quality RCT<\/jats:styled-content>s, mosapride showed an RR<\/jats:styled-content> of 1.114 (95% CI<\/jats:styled-content>: 1.011\u20131.227, P<\/jats:italic>\u2009=\u20090.029). However, in the studies using the R<\/jats:styled-content>ome III criteria for the diagnosis of FD<\/jats:styled-content>, mosapride showed an RR<\/jats:styled-content> of 0.906 (95% CI<\/jats:styled-content>: 0.807\u20131.016, P<\/jats:italic>\u2009=\u20090.092). In the studies having funding source, mosapride showed an RR<\/jats:styled-content> of 1.131 (95% CI<\/jats:styled-content>: 1.028\u20131.244, P<\/jats:italic>\u2009=\u20090.012), whereas an RR<\/jats:styled-content> of 0.966 (95% CI<\/jats:styled-content>: 0.896\u20131.042, P<\/jats:italic>\u2009=\u20090.367) was observed in the studies without funding source. Publication bias was not detected.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this analysis, we could not find a significant effect of mosapride on FD<\/jats:styled-content>. Inconsistent diagnostic criteria for FD<\/jats:styled-content> and different assessment outcomes are causes of heterogeneity. Further studies using common validated outcomes or questionnaires and high\u2010quality RCT<\/jats:styled-content>s will elucidate the real effect of this medication on FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12662","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T02:16:58Z","timestamp":1404699418000},"page":"28-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mosapride treatment for functional dyspepsia: A meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Chang Seok","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwang Ho","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Bong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine Chuncheon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00225.x"},{"key":"e_1_2_6_3_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J. 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