{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:26Z","timestamp":1772160686698,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AstraZeneca"},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ajinomoto Pharmaceutical Co"},{"name":"Bristol-Myers Squibb"},{"name":"Chugai Pharmaceutical Co"},{"DOI":"10.13039\/501100002973","name":"Daiichi Sankyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002975","name":"Dainippon Sumitomo Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002975","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012351","name":"Mitsubishi Tanabe Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012351","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MSD"},{"name":"Otsuka Pharmaceutical Co"},{"name":"Takeda Pharmaceutical Co"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n The single nucleotide polymorphism (\n SNP<\/jats:styled-content>\n ) of interleukin 28\n B<\/jats:styled-content>\n (\n IL28B<\/jats:styled-content>\n ) and the mutations in the\n NS5A<\/jats:styled-content>\n region of hepatitis\n C<\/jats:styled-content>\n virus (\n HCV<\/jats:styled-content>\n ) genotype 1 have been associated with response to interferon (\n IFN<\/jats:styled-content>\n ) therapy. However, these relationships in patients with\n HCV<\/jats:styled-content>\n genotype 2 are not well understood. The aim of this study was to investigate whether the\n SNP<\/jats:styled-content>\n of\n IL28B<\/jats:styled-content>\n (rs8099917) and amino acid substitutions in the\n NS5A<\/jats:styled-content>\n region in patients with\n HCV<\/jats:styled-content>\n genotype 2 affect the response to\n IFN<\/jats:styled-content>\n and ribavirin combination therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study enrolled 286 patients with chronic hepatitis\n C<\/jats:styled-content>\n genotype 2. Patients received pegylated\u2010\n IFN<\/jats:styled-content>\n \u2010alpha 2b once each week plus oral ribavirin daily for 24 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 286 patients, 215 (75.2%) achieved sustained virologic response (\n SVR<\/jats:styled-content>\n ). Rate of\n SVR<\/jats:styled-content>\n was similar in patients with\n IL28B TT<\/jats:styled-content>\n allele (76%) and those with\n TG<\/jats:styled-content>\n or\n GG<\/jats:styled-content>\n alleles (72%). Patients with\n SVR<\/jats:styled-content>\n were younger than those without\n SVR<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009<\u20090.001).\n SVR<\/jats:styled-content>\n was achieved in 65.9% of patients with wild\u2010type\n IFN<\/jats:styled-content>\n sensitivity\u2010determining region (\n ISDR<\/jats:styled-content>\n ) and 83.5% of patients with mutant type (\n P<\/jats:italic>\n \u2009<\u20090.001). There were no significant differences in other factors, including sex, alanine aminotransferase, platelet count,\n HCV<\/jats:styled-content>\n viral load,\n HCV<\/jats:styled-content>\n genotype, and\n IL28B<\/jats:styled-content>\n genotype. The factors related to\n SVR<\/jats:styled-content>\n on multivariate analysis were age (\n P<\/jats:italic>\n \u2009=\u20090.019) and\n ISDR<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ISDR<\/jats:styled-content>\n sequence variations are significantly associated with\n IFN<\/jats:styled-content>\n responsiveness in patients with\n HCV<\/jats:styled-content>\n genotype 2. The\n SNP<\/jats:styled-content>\n of\n IL28B<\/jats:styled-content>\n was not associated with\n SVR<\/jats:styled-content>\n in patients with\n HCV<\/jats:styled-content>\n genotype 2.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12673","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:07:51Z","timestamp":1404432471000},"page":"178-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of interleukin 28\n B<\/scp>\n polymorphism and mutations in the\n NS5A<\/scp>\n region of hepatitis\n C<\/scp>\n virus genotype 2 with interferon responsiveness"],"prefix":"10.1111","volume":"30","author":[{"given":"Kazuhiko","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Nagoya 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