{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:23:26Z","timestamp":1770899006832,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["A120176"],"award-info":[{"award-number":["A120176"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Appendectomy protects against the development of ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>). However, the relationship between appendectomy and the clinical course of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> is complex, and could be impacted by a number of variables. The aim of this study was to compare the clinical course of UC between appendectomized patients and nonappendectomized patients in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 2648 <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients were retrieved from the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nflammatory <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>owel <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease registry at <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>san <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter. This retrospective cohort study compared the clinical course of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> in 68 patients who received an appendectomy before their <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> diagnosis and 2544 patients who did not receive this procedure. A nested case\u2013control study was also conducted to compare the disease course before and after appendectomy in 36 patients who received this surgery after <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> diagnosis. To control for potential confounders, 144 matched controls were retrieved from among 2544 nonappendectomized patients<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the retrospective cohort study, an appendectomy before <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> diagnosis demonstrated no influence on disease extent at diagnosis, rates of medication use, proximal disease extension, or colectomy. The 10\u2010 and 20\u2010year probabilities of receiving a colectomy were 12.7% and 20.6%, respectively, in appendectomized patients, in comparison with 8.9% and 16.4%, respectively, in nonappendectomized patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.81). According to the nested case\u2013control study, an appendectomy after <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> diagnosis did not change the subsequent disease course in terms of medication use, proximal disease extension, or hospital admission rate. The adjusted ratio of hospital admissions after appendectomy <jats:italic>versus<\/jats:italic> before appendectomy was 1.01 (95% confidence interval\u2009=\u20090.46\u20132.23; <jats:italic>P<\/jats:italic>\u2009=\u20090.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appendectomies performed before or after <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> diagnosis do not affect its clinical course in the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12707","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T02:21:01Z","timestamp":1409106061000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Appendectomy and the clinical course of ulcerative colitis: A retrospective cohort study and a nested case\u2013control study from <scp>K<\/scp>orea"],"prefix":"10.1111","volume":"30","author":[{"given":"Ho\u2010Su","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Kyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon\u2010Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Epidemiology University of Ulsan College of Medicine Asan Medical Center  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