{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:07:20Z","timestamp":1791133640707,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai municipal commission of health and family planning","award":["XBR2013125"],"award-info":[{"award-number":["XBR2013125"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n C<\/jats:styled-content>\n rohn's disease is a chronic inflammatory bowel disease. Oridonin is an effective component isolated from\n \n R<\/jats:styled-content>\n abdosia rubescens.\n <\/jats:italic>\n It can inhibit the activation of transcription factor nuclear factor\u2010kappa\n B<\/jats:styled-content>\n and suppress the over expression of cytokines. We postulated that oridonin may be a potential therapeutic candidate for\n C<\/jats:styled-content>\n rohn's disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n To confirm the postulation, we investigated clinical and immunologic modulations of oridonin in a mouse model of trinitrobenzene sulfonic acid\u2010induced colitis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n It was found that oridonin attenuated trinitrobenzene sulfonic acid\u2010induced colitis as represented by a reduction in colonic interferon\u2010\u03b3\/inteleukin\u201017 secretion and a decrement in splenic\n T<\/jats:styled-content>\n h1\/\n T<\/jats:styled-content>\n h17 cells and effector memory\n CD<\/jats:styled-content>\n 4\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells. Oridonin treatment inhibited the proliferation of\n CD<\/jats:styled-content>\n 4\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells and upregulated the apoptosis of lymphocytes by inhibiting nuclear translocation of transcription factor nuclear factor\u2010kappa\n B<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Oridonin is a potential modulator for trinitrobenzene sulfonic acid\u2010induced colitis and other\n T<\/jats:styled-content>\n h1\/\n T<\/jats:styled-content>\n h17 mediated inflammatory diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12710","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T09:39:00Z","timestamp":1410428340000},"page":"504-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Oridonin's therapeutic effect: Suppressing\n T<\/scp>\n h1\/\n T<\/scp>\n h17 simultaneously in a mouse model of\n C<\/scp>\n rohn's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Shubei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saas","sequence":"additional","affiliation":[{"name":"INSERM UMR645 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of 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