{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:50:04Z","timestamp":1768528204138,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"China Program for the Global Fund to Fight TB","award":["TB07-030"],"award-info":[{"award-number":["TB07-030"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072387"],"award-info":[{"award-number":["81072387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["7111006"],"award-info":[{"award-number":["7111006"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>We aimed to explore the effectiveness of preventive usage of hepatoprotectors in patients with tuberculosis (TB<\/jats:styled-content>) receiving anti\u2010TB<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>With stratified cluster sampling strategy, a prospective cohort with 4488 sputum smears positive pulmonary TB<\/jats:styled-content> patients was established from 52 counties of four regions in C<\/jats:styled-content>hina. During anti\u2010TB<\/jats:styled-content> treatment, prescriptions of hepatoprotectors were documented in detail, and liver enzymes were routinely monitored. A<\/jats:styled-content>nti\u2010TB<\/jats:styled-content> drug\u2010induced liver injury (ATLI<\/jats:styled-content>) was assessed based on liver enzymes following the criteria of A<\/jats:styled-content>merican T<\/jats:styled-content>horacic Society. The incidence of ATLI<\/jats:styled-content> between the preventive usage group and reference group was compared by propensity score adjusted C<\/jats:styled-content>ox proportional hazard analysis. Preexisting diseases, history of liver disease, hepatitis B surface antigen status, primary\/re\u2010treatment of TB<\/jats:styled-content>, income per year, and liver enzymes before anti\u2010TB<\/jats:styled-content> treatment were included in the propensity score model.<\/jats:p><\/jats:sec>Results<\/jats:title>After 6\u20139 months of follow\u2010up and monitoring, 4304 patients sustained in our cohort. Two thousand seven hundred fifty\u2010two (63.9%) patients preventively took hepatoprotectors with a median course of 183 days. Most frequently used drugs were H<\/jats:styled-content>u G<\/jats:styled-content>an P<\/jats:styled-content>ian, silymarin, glucurone, and inosine. Two thousand one hundred forty\u2010four (77.9%) patients took those drugs more than 6 months. Sixty\u2010nine (2.4%) patients of preventive usage group and 37 (2.5%) of reference group experienced ATLI<\/jats:styled-content>, respectively. Statistical significances were not found by propensity score analysis for the association between using hepatoprotectors (hazard ratio[HR]\u2009=\u20090.99, 95% confidence interval [CI<\/jats:styled-content>]: 0.65\u20131.52), using hepatoprotectors in the whole course (HR<\/jats:styled-content>\u2009=\u20090.94, 95% CI<\/jats:styled-content>: 0.60\u20131.48), using H<\/jats:styled-content>u G<\/jats:styled-content>an P<\/jats:styled-content>ians, silymarin, glucurone, and inosine with ATLI<\/jats:styled-content> occurrence.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>N<\/jats:styled-content>o preventive effect of hepatoprotectors was observed in patients receiving anti\u2010TB<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12717","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T02:24:34Z","timestamp":1409106274000},"page":"540-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Preventive use of hepatoprotectors yields limited efficacy on the liver toxicity of anti\u2010tuberculosis agents in a large cohort of C<\/scp>hinese patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Shanshan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinyin","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Chongqing Municipality Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiying","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention in Jilin Province Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Tu","sequence":"additional","affiliation":[{"name":"Beijing Institute for Tuberculosis Control Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Global Tuberculosis Control: WHO Report 2012","author":"World Health Organization","year":"2012"},{"key":"e_1_2_7_3_1","volume-title":"An Expanded DOTS Framework for Effective Tuberculosis Control. 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