{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:17Z","timestamp":1792787057885,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intestine Initiative Foundation"},{"name":"Clinical Science and Technology Foundation of Jiangsu Province","award":["BL2014097"],"award-info":[{"award-number":["BL2014097"]}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2012BAI06B03"],"award-info":[{"award-number":["2012BAI06B03"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstact<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n The gut microbiota plays a pivotal role in the intestinal diseases. Fecal microbiota transplantation (\n FMT<\/jats:styled-content>\n ) might be a rescue therapy for refractory inflammatory bowel disease. This study aimed to evaluate the safety, feasibility, and efficacy of\n FMT<\/jats:styled-content>\n through mid\u2010gut for refractory\n C<\/jats:styled-content>\n rohn's disease (\n CD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We established standardized laboratory protocol and clinical work flow for\n FMT<\/jats:styled-content>\n . Only refractory\n CD<\/jats:styled-content>\n patients with\n H<\/jats:styled-content>\n arvey\u2013\n B<\/jats:styled-content>\n radshaw\n I<\/jats:styled-content>\n ndex (\n HBI<\/jats:styled-content>\n ) score\u2009\u2265\u20097 were enrolled for this study. All included patients were treated with single\n FMT<\/jats:styled-content>\n through mid\u2010gut and assessed during follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Metagenomics analysis showed a high concordance between feces sample and purified fecal microbiota from same donors. Standardized fecal microbiota preparation and clinical flow significantly simplified the practical aspects of\n FMT<\/jats:styled-content>\n . Totally, 30 patients were qualified for the present analysis. The rate of clinical improvement and remission based on clinical activity at the first month was 86.7% (26\/30) and 76.7% (23\/30), respectively, which was higher than other assessment points within 15\u2010month follow\u2010up. Patients' body weight increased after\n FMT<\/jats:styled-content>\n , and the lipid profile improved as well.\n FMT<\/jats:styled-content>\n also showed a fast and continuous significant effect in relieving the sustaining abdominal pain associated with sustaining\n CD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is a pilot study with the largest sample of patients with refractory\n CD<\/jats:styled-content>\n who underwent single\n FMT<\/jats:styled-content>\n . The results demonstrated that\n FMT<\/jats:styled-content>\n through mid\u2010gut might be a safe, feasible, and efficient rescue therapy for refractory\n CD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12727","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T08:35:34Z","timestamp":1409214934000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":278,"title":["Fecal microbiota transplantation through mid\u2010gut for refractory\n C<\/scp>\n rohn's disease: Safety, feasibility, and efficacy trial results"],"prefix":"10.1111","volume":"30","author":[{"given":"Bota","family":"Cui","sequence":"first","affiliation":[{"name":"Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University Nanjing 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