{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:05:04Z","timestamp":1771041904455,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Approximately more than half of patients with non\u2010erosive reflux disease (NERD<\/jats:styled-content>) do not respond to proton pump inhibitor (PPI<\/jats:styled-content>) therapy. Although NERD<\/jats:styled-content> is a heterogeneous entity, previous study showed that multichannel intraluminal impedance (MII<\/jats:styled-content>)\u2010pH<\/jats:styled-content> monitoring could distinguish reflux\u2010related disease from PPI<\/jats:styled-content>\u2010refractory NERD<\/jats:styled-content>. The aim of this study was to examine the usefulness of baseline impedance in PPI<\/jats:styled-content>\u2010refractory NERD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used MII<\/jats:styled-content>\u2010pH<\/jats:styled-content> monitoring to analyze reflux parameters, symptom index (SI<\/jats:styled-content>), and baseline impedance in 37 PPI<\/jats:styled-content>\u2010refractory NERD<\/jats:styled-content> patients on PPI<\/jats:styled-content>. Reflux was divided into acid (nadir pH<\/jats:styled-content>\u2009\u2264\u20094) and non\u2010acid (nadir pH<\/jats:styled-content>\u2009>\u20094). Subjects were classified as having reflux\u2010related disease based on abnormal reflux parameters or positive SI<\/jats:styled-content> (\u2265\u200950%), or non\u2010reflux\u2010related disease, including functional heartburn, based on negative SI<\/jats:styled-content> with normal reflux parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 26 of the 37 subjects were diagnosed with reflux\u2010related disease, including eight with acid\u2010reflux type and 18 with non\u2010acid\u2010reflux type, and nine with functional heartburn and two with pseudohypersalivation. There were no significant differences in the clinical characteristics of the acid\u2010reflux type, non\u2010acid\u2010reflux type, and functional heartburn groups. The baseline impedance value in the acid\u2010reflux type (1245\u2009\u00b1\u2009392 \u03a9) was significantly lower than that in the non\u2010acid\u2010reflux type (2824\u2009\u00b1\u20091160 \u03a9) and functional heartburn (3546\u2009\u00b1\u20091353 \u03a9) groups. Baseline impedance values inversely correlated with reflux percent time, acid\u2010reflux time, and acid exposure time.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Among patients with PPI<\/jats:styled-content>\u2010refractory NERD<\/jats:styled-content>, acid\u2010reflux type was associated with lower baseline impedance compared with non\u2010acid\u2010reflux type and functional heartburn.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12743","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T19:50:10Z","timestamp":1428004210000},"page":"36-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Usefulness of baseline impedance in patients with proton pump inhibitor\u2010refractory nonerosive reflux disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Yukie","family":"Kohata","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0047-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226088"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00288-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03350.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3123"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145581"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07074.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.276"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0689-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.3.G457"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00711.x"},{"key":"e_1_2_5_14_1","first-page":"358","article-title":"The symptom index: a clinically important parameter of ambulatory 24\u2010hour esophageal pH monitoring","volume":"83","author":"Wiener GJ","year":"1988","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"e_1_2_5_15_1","first-page":"A171","article-title":"Normal values for ambulatory 24\u2010h combined impedance\u2010pH monitoring on acid suppressive therapy","volume":"130","author":"Tutuian R","year":"2006","journal-title":"Gastroenterology"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04172.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02677.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.3.327"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.060"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02185.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.10.004"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.233049"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40978.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.194191"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T10:34:43Z","timestamp":1694514883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jgh.12743"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12743","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2015-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}