{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:45:10Z","timestamp":1694630710830},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This prospective pilot study investigated whether it is possible to predict the therapeutic response in both the early phase (1 week) and sustained phase (4 weeks) before starting proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) therapy for functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) or non\u2010erosive reflux disease (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We administered rabeprazole 10\u2009mg for 4 weeks to <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients, who also answered a modified version of the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>requency <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptoms of gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">FSSG<\/jats:styled-content>), which added a pain score to the <jats:styled-content style=\"fixed-case\">FSSG<\/jats:styled-content>. Total score (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>), reflux score (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>), dysmotility score (<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>), and pain score (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) were analyzed. Symptom improvement was defined as\u2009\u2265\u200950% improvement in each score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 83 patients (age [mean\u2009\u00b1\u2009<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>] 50.8\u2009\u00b1\u200915.8 years, 29 males, 54 females), of whom 62 could be classified into four groups: achieved symptom improvement within 1 week and maintained it for 4 weeks (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>arly\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, 40.3%); achieved symptom improvement within 1 week but lost it after 4 weeks (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>emp\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, 9.7%); did not achieve symptom improvement within 1 week but did after 4 weeks (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ate\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, 9.7%); and no improvement (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>on\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, 40.3%). Mean <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>on\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> group were significantly higher than in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>arly\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> group (23.9, 10.5, 11.0, and 2.4 <jats:italic>vs<\/jats:italic> 14.3, 6.8, 6.4, and 1.2). However, the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>emp\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ate\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>on\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> groups could not be distinguished by <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The magnitude of the pretreatment modified <jats:styled-content style=\"fixed-case\">FSSG<\/jats:styled-content> score seemed to be associated with the response at 1 week and 4 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12744","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T19:50:10Z","timestamp":1428004210000},"page":"25-30","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pretreatment prediction of symptom response to proton pump inhibitor therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Akihito","family":"Nagahara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06218.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230X\u201012\u201042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01651.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02983.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03410.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1417-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06249.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0382-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.5678"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0503-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0446-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03619.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01363.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90033-7"},{"key":"e_1_2_6_16_1","first-page":"995","article-title":"Burden of common mental disorders in patients with functional dyspepsia","volume":"60","author":"Sattar A","year":"2010","journal-title":"J. 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