{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:30:10Z","timestamp":1791153010405,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Secondary stomach cancer in lesions of the remnant stomach occurs relatively soon after distal gastrectomy using the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>illroth <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> reconstruction procedure. Prophylactic eradication of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> after endoscopic resection of early gastric cancer should be used to prevent the development of metachronous gastric carcinoma. However, the effect of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication on the gastric remnant has not been clearly determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight patients who were <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010positive after distal gastrectomy for primary gastric cancer underwent eradication therapy and were followed by endoscopy for 9 years. Upper gastroenteroscopy series were done before and at 1, 3, 5, 7 and 9 years after eradication, and biopsy specimens were taken from the lesser and greater curvatures, respectively. Histological changes, including chronic inflammation, activity, atrophy, and intestinal metaplasia, were evaluated using the updated <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ydney system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Successful eradication was confirmed using the urea breath test in all eight patients. Chronic inflammation scores were improved after eradication at both the lesser (mean scores\u2009\u00b1\u2009<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: before eradication, 2.9\u2009\u00b1\u20090.5; 1 year after, 2.3\u2009\u00b1\u20090.4; 3 years, 1.8\u2009\u00b1\u20090.3; 5 years, 1.5\u2009\u00b1\u20090.3; 7 years, 1.3\u2009\u00b1\u20090.3; and 9 years, 1.0\u2009\u00b1\u20090.3) and greater curvatures (before, 2.9\u2009\u00b1\u20090.4; 1 year after, 1.9\u2009\u00b1\u20090.3; 3 years, 1.4\u2009\u00b1\u20090.4; 5 years, 1.3\u2009\u00b1\u20090.3; 7 years, 1.1\u2009\u00b1\u20090.2; and 9 years, 0.6\u2009\u00b1\u20090.3). Atrophy scores improved more quickly after eradication than chronic inflammation scores at both the lesser (before, 2.4\u2009\u00b1\u20090.5; 1 year after, 1.8\u2009\u00b1\u20090.4; 3 years, 0.8\u2009\u00b1\u20090.3; 5 years, 0.3\u2009\u00b1\u20090.1; 7 years, 0.0; and 9 years, 0.0) and greater curvatures (before, 2.2\u2009\u00b1\u20090.4; 1 year after, 1.3\u2009\u00b1\u20090.3; 3 years, 0.5\u2009\u00b1\u20090.3; 5 years, 0.0; 7 years, 0.0; and 9 years, 0.0). No secondary stomach cancers were found on endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Undergoing <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication improved possible precancerous lesions of the gastric remnant among patients who had undergone distal gastrectomy. Prophylactic <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication in the gastric remnant may be useful in preventing the development of metachronous gastric carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12772","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T17:13:10Z","timestamp":1419181990000},"page":"60-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Usefulness of <i><scp>H<\/scp>elicobacter pylori<\/i> eradication for precancerous lesions of the gastric remnant"],"prefix":"10.1111","volume":"29","author":[{"given":"Masatoshi","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Gastroenterology Aichi Cancer Center Aichi Hospital  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Morise","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Funasaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301647"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016860"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199800001-00025"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1337-y"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05447.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_12_1","series-title":"IARC monographs on the evaluation of carcinogenic risks to humans","volume-title":"Schistosomes, Liver Flukes and Helicobacter Pylori","author":"International Agency for Research on Cancer","year":"1994"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350206"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_5_15_1","first-page":"4255","article-title":"Development of Helicobacter pylori\u2010induced gastric carcinoma in Mongolian gerbils","volume":"58","author":"Honda S","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1128\/IAI.66.10.4742-4747.1998","article-title":"Differential normalization of mucosal interleukin\u20108 and interleukin\u20106 activity after Helicobacter pylori eradication","volume":"66","author":"Ando T","year":"1998","journal-title":"Infect. Immun."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92193-8"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7133.746"}],"updated-by":[{"DOI":"10.1111\/jgh.14523","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"record-id":"19686"},{"DOI":"10.1111\/jgh.14523","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000}}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12772","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:39:08Z","timestamp":1694587148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":17,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jgh.12772"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12772","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"2014-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}