{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:31:59Z","timestamp":1777725119020,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["22590690"],"award-info":[{"award-number":["22590690"]}]},{"name":"JSPS KAKENHI","award":["23790155"],"award-info":[{"award-number":["23790155"]}]},{"name":"JSPS KAKENHI","award":["21590491"],"award-info":[{"award-number":["21590491"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The hepatocyte growth factor (HGF<\/jats:styled-content>)\/c\u2010M<\/jats:styled-content>et pathway has attracted attention in the formation of malignant tumors, as HGF<\/jats:styled-content> secreted from the microcirculatory components as well as residing macrophages has been suggested to act on the c\u2010M<\/jats:styled-content>et receptors of cancer cells to decrease apoptosis and increase proliferation, invasion, and metastasis. The present study was undertaken to elucidate the interaction of the gastric, hepatic, and pulmonary mucosa\u2010associated lymphoid tissue (MALT<\/jats:styled-content>) lymphoma induced by H<\/jats:styled-content>elicobacter heilmannii<\/jats:italic> infection with c\u2010M<\/jats:styled-content>et and HGF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>C<\/jats:styled-content>57BL<\/jats:styled-content>\/6 female mice, infected with H<\/jats:styled-content>.\u2009heilmannii<\/jats:italic> for 3 months were used. The localization of the HGF<\/jats:styled-content>, c\u2010M<\/jats:styled-content>et, and HGF<\/jats:styled-content> activator immunoreactivities was observed by the indirect immunohistochemical methods. In addition, the effect of c\u2010M<\/jats:styled-content>et antibody and c\u2010M<\/jats:styled-content>et inhibitor, PHA<\/jats:styled-content>\u2010665752, was also investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>c\u2010M<\/jats:styled-content>et immunoreactivity was found in the lymphocytes composing the MALT<\/jats:styled-content> lymphoma, and HGF<\/jats:styled-content> immunoreactivity was recognized mostly in the endothelial cells and macrophages in the MALT<\/jats:styled-content> lymphoma. HGFA<\/jats:styled-content> was localized on mesenchymal cells other than the lymphocytes. The administration of the antibody against c\u2010M<\/jats:styled-content>et or the c\u2010M<\/jats:styled-content>et inhibitor to the infected mice induced the significant suppression of hepatic and pulmonary MALT<\/jats:styled-content> lymphoma, while the gastric MALT<\/jats:styled-content> lymphoma showed only a tendency to decrease in size, while the active caspase 3 positive cells markedly decreased in the gastric, hepatic, and pulmonary MALT<\/jats:styled-content> lymphoma after the treatment with the c\u2010M<\/jats:styled-content>et antibody or the c\u2010Met antagonist.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HGF<\/jats:styled-content> and c\u2010M<\/jats:styled-content>et pathway were suggested to contribute to the lymphomagenesis in the MALT<\/jats:styled-content> lymphoma after H<\/jats:styled-content>.\u2009heilmannii<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12776","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T17:13:10Z","timestamp":1419181990000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alteration of angiogenesis in H<\/scp>elicobacter heilmannii<\/i>\u2010induced mucosa\u2010associated lymphoid tissue lymphoma: Interaction with c\u2010M<\/scp>et and hepatocyte growth factor"],"prefix":"10.1111","volume":"29","author":[{"given":"Masahiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Pathophysiology, Research and Education Center for Clinical Pharmacy School of Pharmaceutical Sciences Kitasato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsufumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Pathophysiology, Research and Education Center for Clinical Pharmacy School of Pharmaceutical Sciences Kitasato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Matsui","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences Kitasato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Baniwa","sequence":"additional","affiliation":[{"name":"Division of Pathophysiology, Research and Education Center for Clinical Pharmacy School of Pharmaceutical Sciences Kitasato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine Kyorin University Mitaka Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somay Y","family":"Murayama","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology School of Pharmacy Nihon University Funabashi Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kitasato Institute Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kitasato Institute Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01459-06"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01662-07"},{"key":"e_1_2_6_4_1","first-page":"A99","article-title":"Isolation of Helicobacter Heilmannii like organism from the stomachs of cynomolgus monkeys and colonization of them in mice","volume":"106","author":"Itoh T","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0281-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04483"},{"key":"e_1_2_6_8_1","first-page":"985","article-title":"Heterogeneity of malignant non\u2010Hodgkin lymphoma\u2010associated blood vessels","volume":"53","author":"Du\u015fe AO","year":"2012","journal-title":"Rom. 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