{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:11:21Z","timestamp":1792613481923,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study assessed the utility of a simple organ failure count (<jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content>) in predicting the in\u2010hospital mortality in patients with acute\u2010on\u2010chronic liver failure (<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>) compared with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hronic <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ailure <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>cute\u2010on\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hronic <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ailure in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>irrhosis (<jats:styled-content style=\"fixed-case\">CANONIC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> grading system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients of <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> were included prospectively from 2012 to 2013. The diagnosis was based on <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>acific <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssociation for the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy of the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver (<jats:styled-content style=\"fixed-case\">APASL<\/jats:styled-content>) criteria except for the inclusion of non\u2010hepatic insults as acute events. Organ failures were defined as per the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hronic <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ailure\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>equential <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rgan <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ailure <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment system. <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> was calculated as the simple number of organ failures from 0 to 6. In\u2010hospital mortality was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Majority (92[87%]) of the 106 patients included were males, had alcohol (76[72%]) as the etiology of cirrhosis, and alcoholic hepatitis (58[55%]) as the acute precipitating event. Overall, 51(48%) patients died in\u2010hospital. In\u2010hospital mortality in patients with <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> of 0 (<jats:italic>n<\/jats:italic>\u2009=\u20099), 1 (<jats:italic>n<\/jats:italic>\u2009=\u200939), 2 (<jats:italic>n<\/jats:italic>\u2009=\u200924), 3 (<jats:italic>n<\/jats:italic>\u2009=\u200924), 4 (<jats:italic>n<\/jats:italic>\u2009=\u20097), and 5 (<jats:italic>n<\/jats:italic>\u2009=\u20093) was 0%, 26%, 58%, 71%, 100%, and 100% respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), whereas it was 10%, 30%, 58%, and 79% in patients with no\u2010<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200921), grades 1 (<jats:italic>n<\/jats:italic>\u2009=\u200927), 2 (<jats:italic>n<\/jats:italic>\u2009=\u200924), and 3 <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200934) respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Patients with no\u2010<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200921) had higher mortality than <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> 0 as they included 9 patients with <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> 0 (0% mortality) and 12 patients with <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> 1 (17% mortality). Mortality was similar between 12 no\u2010<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> and 27 grade 1 <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.462) that comprised <jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SOFC<\/jats:styled-content> is a simpler and better method than the <jats:styled-content style=\"fixed-case\">CANONIC<\/jats:styled-content> grading system for predicting the in\u2010hospital mortality in patients with <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> defined as per <jats:styled-content style=\"fixed-case\">APASL<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12778","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T08:14:55Z","timestamp":1411460095000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Simple organ failure count <i>versus<\/i>\u2005<scp>CANONIC<\/scp> grading system for predicting mortality in acute\u2010on\u2010chronic liver failure"],"prefix":"10.1111","volume":"30","author":[{"given":"Swastik","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Duseja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh 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