{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:51Z","timestamp":1788871851941,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund for the Control of Infectious Diseases","award":["11100372"],"award-info":[{"award-number":["11100372"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n The prognostic role of noninvasive assessments of liver fibrosis has been evolving. Our aim was to investigate the prognostic value of liver stiffness measurement (\n LSM<\/jats:styled-content>\n ) with transient elastography and serum\u2010based\n H<\/jats:styled-content>\n ui index to predict hepatic events and deaths in chronic hepatitis\n B<\/jats:styled-content>\n (\n CHB<\/jats:styled-content>\n ) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The main prospective cohort included 1555 consecutive\n CHB<\/jats:styled-content>\n patients referred for transient elastography examination; a subgroup of 980 patients underwent follow\u2010up assessments at least 3 years later formed the serial cohort. Cox proportional hazard model was performed to determine the relationship of\n LSM<\/jats:styled-content>\n ,\n H<\/jats:styled-content>\n ui index and other clinical variables with hepatic events and deaths.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During a mean follow\u2010up of 69\u2009\u00b1\u20099 months, 119 patients (7.6%) developed hepatic events or deaths. Hepatic event\u2010free survival was significantly decreased with increasing stages of\n LSM<\/jats:styled-content>\n and\n H<\/jats:styled-content>\n ui index. The 5\u2010year cumulative probability of hepatic event\u2010free survival of patients of\n S<\/jats:styled-content>\n tage 1\u20137 of\n LSM<\/jats:styled-content>\n were 99.3%, 98.8%, 95.7%, 90.9%, 89.6%, 74.6%, and 50.0%, respectively; that of\n S<\/jats:styled-content>\n tage 1 to 3 of\n H<\/jats:styled-content>\n ui index were 98.2%, 93.1%, and 77.5%, respectively. Independent predictors of hepatic event\u2010free survival were age, baseline\n LSM<\/jats:styled-content>\n , and follow\u2010up\n H<\/jats:styled-content>\n ui index. Serum\n ALT<\/jats:styled-content>\n and body mass index affected the accuracy of prediction by\n LSM<\/jats:styled-content>\n . Patients remained early stages of\n LSM<\/jats:styled-content>\n or\n H<\/jats:styled-content>\n ui index at follow\u2010up visit had better survival compared to those remained at late stages.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Baseline and change in noninvasive parameters of liver fibrosis,\n LSM<\/jats:styled-content>\n and\n H<\/jats:styled-content>\n ui index, are accurate to predict hepatic event\u2010free survival in\n CHB<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12779","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T04:03:29Z","timestamp":1411445009000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Noninvasive assessments of liver fibrosis with transient elastography and\n H<\/scp>\n ui index predict survival in patients with chronic hepatitis\n B<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"first","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Ka\u2010Yan","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Po\u2010Lai","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace Yim","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Chi\u2010Yee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan Cham\u2010Yan","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel Mei\u2010Ling","family":"Chim","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Kit\u2010Ting","family":"Lau","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi\u2010Yun","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong SAR 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