{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:18:23Z","timestamp":1777681103917,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic>) infection is a strong risk factor for the development of gastric cancer. In 2013, the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese government approved <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first\u2010line <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication therapies is an urgent problem. In this study, we investigated changes in the first\u2010line eradication rate from 2001 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eradication rates for 7\u2010day triple therapy [proton pump inhibitor (rabeprazole 20\u2009mg, lansoprazole 60\u2009mg, or omeprazole 40\u2009mg)\u2009+\u2009amoxicillin 1500\u2009mg\u2009+\u2009clarithromycin (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>) 400 or 800\u2009mg, daily] were collated from 14 hospitals in the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>okyo metropolitan area. The urea breath test was used for the evaluation of eradication. The cut\u2010off value was less than 2.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The yearly eradication rates (intention to treat\/per protocol) were 78.5\/79.5% (2001, <jats:italic>n<\/jats:italic>\u2009=\u2009242), 71.2%\/72.9% (2002, <jats:italic>n<\/jats:italic>\u2009=\u2009208), 67.8%\/70.5% (2003, <jats:italic>n<\/jats:italic>\u2009=\u2009183), 75.6%\/84.6% (2004, <jats:italic>n<\/jats:italic>\u2009=\u2009131), 56.4%\/70.5% (2005, <jats:italic>n<\/jats:italic>\u2009=\u2009114), 70.5%\/75.8% (2006, <jats:italic>n<\/jats:italic>\u2009=\u2009271), 67.4%\/82.0% (2007,<jats:italic>n<\/jats:italic>\u2009=\u2009135), 64.0%\/76.3% (2008, <jats:italic>n<\/jats:italic>\u2009=\u2009261), 60.5%\/74.3% (2009, <jats:italic>n<\/jats:italic>\u2009=\u2009329), and 66.5%\/78.8% (2010, <jats:italic>n<\/jats:italic>\u2009=\u2009370), respectively. Examination of eradication rates according to <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> dosage revealed an eradication rate of 65.6% (383\/584) for <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> 400\u2009mg daily, and 68.5% (1124\/1642) for <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> 800\u2009mg daily, with no significant difference seen between dosages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In recent years, eradication rates for first\u2010line triple therapy have obviously decreased, but no noticeable decrease has occurred after 2001.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12796","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T17:13:10Z","timestamp":1419181990000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Changes in the first line <i><scp>H<\/scp>elicobacter pylori<\/i> eradication rates using the triple therapy\u2013a multicenter study in the <scp>T<\/scp>okyo metropolitan area (Tokyo <i>Helicobacter pylori<\/i> study group)"],"prefix":"10.1111","volume":"29","author":[{"given":"Takashi","family":"Kawai","sequence":"first","affiliation":[{"name":"Endoscopy Center Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin'ichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Matsuhisa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Endoscopy Tama\u2010Nagayama University Hospital of Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiro","family":"Masaoaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Hospital Organization Tokyo Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Hospital Organization Tokyo Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Yotsuya Medical Cube Nerima General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Surgery Nerima General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Omata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nihon University, School and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Torii","sequence":"additional","affiliation":[{"name":"Torii Medical Clinic Foundation for Detection of Early Gastric Cancer  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of General Medicine &amp; 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