{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:29:19Z","timestamp":1768883359709,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver biopsy\u2010based studies have shown that serum levels of aminotransferases are lower than conventional cut\u2010off of 40\u2009IU\/mL in persons with normal histology. There is no such study in<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndian population based on liver histology. This study aims to estimate normal values of serum aminotransferases in healthy<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndian population with normal liver histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study includes all liver donors who underwent liver donation at our centre and had a preoperative liver biopsy done for various reasons. All the donors had negative viral markers. Nonalcoholic fatty liver (<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>) was defined as &gt;\u20095% hepatocytes having steatosis and no changes of steatohepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 331 donors (147 males) with the ages of 35.7\u2009\u00b1\u200910.2 years.<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>was present in 167 donors (50.4%). In comparison with male donors with normal histology (<jats:italic>n<\/jats:italic>\u2009=\u200967), donors with<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>(<jats:italic>n<\/jats:italic>\u2009=\u200980) had significantly higher age, body mass index, aspartate aminotransferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>), alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>), alkaline phosphatase, gamma\u2010glutamyl transpeptidase, total cholesterol, low\u2010density lipoprotein, and fasting blood sugar. In comparison with female donors with normal histology, donors with<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>had significantly higher body mass index,<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>, and triglycerides; however, there was no significant difference regarding other parameters. Of the<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>in normal histology donors, 95th percentile were 33.8\u2009IU\/L and 38.6\u2009IU\/L for males and 31\u2009IU\/L and 35.2\u2009IU\/L for females. Twenty\u2010five donors had lean<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>(body mass index &lt;\u200923\u2009kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum aminotransferase values in healthy<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndian population with normal histology are provided. Histological<jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>is present in half of apparently normal donors, and it has different clinical and biochemical associations in males and females.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12836","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T02:10:11Z","timestamp":1414548611000},"page":"763-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Estimation of normal values of serum transaminases based on liver histology in healthy<scp>A<\/scp>sian<scp>I<\/scp>ndians"],"prefix":"10.1111","volume":"30","author":[{"given":"Narendra S","family":"Choudhary","sequence":"first","affiliation":[{"name":"Medanta Liver Institute Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Saraf","sequence":"additional","affiliation":[{"name":"Medanta Liver Institute Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Saigal","sequence":"additional","affiliation":[{"name":"Medanta Liver Institute Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Histopathology Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipika","family":"Lipi","sequence":"additional","affiliation":[{"name":"Department of Histopathology Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvinder S","family":"Soin","sequence":"additional","affiliation":[{"name":"Medanta Liver Institute Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/clinchem\/21.8.1077","article-title":"Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values","volume":"21","author":"Siest G","year":"1975","journal-title":"Clin. 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