{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:21:16Z","timestamp":1790130076124,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>It has been reported that small intestinal bacterial overgrowth (<jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content>) may lead to false positive diagnoses of lactose malabsorption (<jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>) in irritable bowel syndrome patients. The aim of this study was to determine the influence of <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content> on lactose hydrogen breath test (<jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>) results in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diarrhea\u2010predominant irritable bowel syndrome patients with abnormal lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>s ingested a test meal containing <jats:sup>99m<\/jats:sup><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c and lactose. The location of the test meal and the breath levels of hydrogen were recorded simultaneously by scintigraphic scanning and lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>, respectively. The increase in hydrogen concentration was not considered to be caused by <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content> if \u2265\u200910% of <jats:sup>99m<\/jats:sup><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c accumulated in the cecal region at the time or before of abnormal lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content> was present in 84% (31\/37) of irritable bowel syndrome patients. Twenty of these patients agreed to measurement of oro\u2010cecal transit time. Only three patients (15%) with abnormal lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content> might have had <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content>. The median oro\u2010cecal transit time between <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content> and lactose intolerance patients were 75\u2009min and 45\u2009min, respectively (Z\u2009=\u20092.545, <jats:italic>P<\/jats:italic>\u2009=\u20090.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most of irritable bowel syndrome patients with an abnormal lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content> had little impact on the interpretation of lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>s. The patients with lactose intolerance had faster small intestinal transit than <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12862","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T23:18:11Z","timestamp":1417648691000},"page":"995-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea\u2010predominant irritable bowel syndrome in <scp>A<\/scp>sia"],"prefix":"10.1111","volume":"30","author":[{"given":"Yilin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishou","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00339-7"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Methodology and indications of H2\u2010breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"1","author":"Gasbarrini A","year":"2009","journal-title":"Aliment. 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