{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:42:45Z","timestamp":1696315365339},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Takeda Pharmaceutical Company Limited"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010erosive reflux disease (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>) and functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) share some common features, and the appropriateness of managing these diseases independently has been questioned. A post\u2010hoc subgroup analysis of the <jats:styled-content style=\"fixed-case\">LEGEND<\/jats:styled-content> study was performed to compare demographics and treatment response between patients with <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with reflux and dyspepsia symptoms who had no endoscopic evidence of mucosal breaks and\/or erosions were included and divided into groups with predominant NERD (<jats:italic>n<\/jats:italic>\u2009=\u20091546) or FD (<jats:italic>n<\/jats:italic>\u2009=\u2009614). Patients received lansoprazole for 4 weeks, and their symptoms were evaluated using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients were significantly younger than <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> patients (54 <jats:italic>vs<\/jats:italic> 60 years), more likely to have a body mass index &lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> (72.4% <jats:italic>vs<\/jats:italic> 67.1%), less likely to have a hiatal hernia (24.0% <jats:italic>vs<\/jats:italic> 31.2%), and more likely to feel continuous stress (54.7% <jats:italic>vs<\/jats:italic> 48.0%). After 4 weeks of treatment, &gt;\u200960% of both patients reported an improvement in reflux symptoms and in most dyspepsia symptoms. The improvement rate for reflux symptoms was lower in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients than in <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), whereas the improvement rate for dyspepsia symptoms did not differ between patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although no clinically significant differences in pathophysiology exist between <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, there are some between\u2010group differences in demographic characteristics and improvement rates for reflux symptoms after treatment with lansoprazole. It remains to be discussed whether it is necessary to make a strict differential diagnosis between these two conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12877","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T08:57:13Z","timestamp":1420448233000},"page":"834-841","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Demography and treatment response in patients with predominant non\u2010erosive reflux disease or functional dyspepsia"],"prefix":"10.1111","volume":"30","author":[{"given":"Hiroto","family":"Miwa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine  Hyogo Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kawasaki Medical School  Kurashiki City Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Takeda Pharmaceutical Company Limited  Osaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Sanada","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Takeda Pharmaceutical Company Limited  Osaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinzo","family":"Hiroi","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Takeda Pharmaceutical Company Limited  Osaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shimane University School of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2087-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053355"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.01.008"},{"key":"e_1_2_6_7_1","first-page":"261","article-title":"Functional dyspepsia and non\u2010erosive reflux disease. 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