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The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin\u20108 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108) is an important mediator of inflammation and the immune response in human disease. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 is overexpressed in <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 in <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jgh.12900","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T10:31:46Z","timestamp":1421922706000},"page":"970-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Interleukin\u20108: A critical chemokine in biliary atresia"],"prefix":"10.1111","volume":"30","author":[{"given":"Rui","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital of Fudan University  Shanghai China"},{"name":"Key Laboratory of Neonatal Disease Ministry of Health  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital of Fudan University  Shanghai China"},{"name":"Key Laboratory of Neonatal Disease Ministry of Health  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2383"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-009-0081-8"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-008-0024-8"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200411000-00017"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.33840"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.01.012"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000130480.51066.FB"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91122-K"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)00013-3"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000050"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12375"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.04.011"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2011.1438"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24739"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021381"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60509-X"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.675"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00016-8"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2011.618902"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-226"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11603-5"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35820"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.09.012"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-004-1329-x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700490"},{"key":"e_1_2_4_27_1","first-page":"1","article-title":"Biliary atresia and inflammation: from pathogenesis to prognosis","volume":"32","author":"Srivastava A","year":"2011","journal-title":"Trop. 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