{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:14:03Z","timestamp":1779923643410,"version":"3.53.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Hepatocellular carcinoma (\n HCC<\/jats:styled-content>\n ) can develop in patients with chronic hepatitis\n C<\/jats:styled-content>\n after they have achieved a sustained virologic response (\n SVR<\/jats:styled-content>\n ) to antiviral therapy, that is eradication of hepatitis\n C<\/jats:styled-content>\n virus (\n HCV<\/jats:styled-content>\n ). Thus, surveillance for\n HCC<\/jats:styled-content>\n remains necessary after\n SVR<\/jats:styled-content>\n . We investigated factors that are predictive of\n HCC<\/jats:styled-content>\n in\n HCV<\/jats:styled-content>\n \u2010infected patients who achieved\n SVR<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The incidence and risk factors for\n HCC<\/jats:styled-content>\n were evaluated in 522 patients who achieved\n SVR<\/jats:styled-content>\n with interferon\u2010based antiviral therapy for\n HCV<\/jats:styled-content>\n . Patients maintained regular follow\u2010up every 6 months for\n HCC<\/jats:styled-content>\n surveillance. The\n F<\/jats:styled-content>\n IB<\/jats:styled-content>\n \u20104 index and aspartate aminotransferase to platelet count ratio index were calculated based on laboratory data at the time that\n SVR<\/jats:styled-content>\n was documented (\n SVR<\/jats:styled-content>\n 24).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients continued follow\u2010up visits for 1.0\u201322.9 years (median, 7.2 years) after\n SVR<\/jats:styled-content>\n .\n HCC<\/jats:styled-content>\n developed in 18 patients. The incidence of\n HCC<\/jats:styled-content>\n was 1.2% at 5 years and 4.3% at 10 years. The use of peginterferon or ribavirin for treatment and a history of antiviral therapy prior to the course when\n SVR<\/jats:styled-content>\n was achieved were not associated with the incidence of\n HCC<\/jats:styled-content>\n after\n SVR<\/jats:styled-content>\n . The presence of diabetes mellitus (risk ratio 2.08;\n P<\/jats:italic>\n \u2009=\u20090.0451) and\n FIB<\/jats:styled-content>\n \u20104 index calculated at the time of\n SVR24<\/jats:styled-content>\n (risk ratio 1.73;\n P<\/jats:italic>\n \u2009=\u20090.0198) were associated with a higher likelihood of\n HCC<\/jats:styled-content>\n after\n SVR<\/jats:styled-content>\n by multivariate analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with diabetes mellitus and patients with the elevation of\n FIB<\/jats:styled-content>\n \u20104 index at\n SVR<\/jats:styled-content>\n 24 are at higher risk of\n HCC<\/jats:styled-content>\n after\n SVR<\/jats:styled-content>\n . Surveillance for\n HCC<\/jats:styled-content>\n should be continued in this patient subpopulation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12915","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T08:21:59Z","timestamp":1423815719000},"page":"1183-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Risk factors of hepatocellular carcinoma development in non\u2010cirrhotic patients with sustained virologic response for chronic hepatitis\n C<\/scp>\n virus infection"],"prefix":"10.1111","volume":"30","author":[{"given":"Hidenori","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital Ogaki 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