{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:25:30Z","timestamp":1788780330661,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC<\/jats:styled-content>). We aimed to investigate the prognostic significance of a new prognostic score, the albumin\u2010bilirubin (ALBI<\/jats:styled-content>) score, among PBC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>In a retrospective longitudinal cohort of 61 C<\/jats:styled-content>hinese PBC<\/jats:styled-content> patients with follow\u2010up period up to 18.3 years, the prognostic performance of the ALBI<\/jats:styled-content> in prediction of hepatic events was compared with other well\u2010established prognostic scores: C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh score, model of end\u2010stage liver disease, M<\/jats:styled-content>ayo risk score, Y<\/jats:styled-content>ale, E<\/jats:styled-content>uropean, and N<\/jats:styled-content>ewcastle models.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifteen patients (24.6%) developed hepatic events during follow\u2010up. The c\u2010index (0.894) and \u03c72<\/jats:sup> by likelihood ratio test (36.34) of the ALBI<\/jats:styled-content> score were highest in comparison to other models. The ALBI<\/jats:styled-content> score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P<\/jats:italic>\u2009<\u20090.001). There were three prognostically different groups stratified by the ALBI<\/jats:styled-content> score: ALBI<\/jats:styled-content> grade 1 (\u2264\u2009\u22122.60), grade 2 (>\u2009\u22122.60 to \u22121.39), and grade 3 (>\u2009\u22121.39) groups. The 2\u2010, 5\u2010, and 10\u2010year event\u2010free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus<\/jats:italic> 100.0% versus<\/jats:italic> 57.1%, 100.0% versus<\/jats:italic> 88.5% versus<\/jats:italic> 14.3%, and 100.0% versus<\/jats:italic> 81.7% versus<\/jats:italic> 0.0%, respectively (P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The ALBI<\/jats:styled-content> score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC<\/jats:styled-content> patients and provides better\/similar prognostic performance compared with other prognostic scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12938","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T01:44:56Z","timestamp":1425951896000},"page":"1391-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["New simple prognostic score for primary biliary cirrhosis: Albumin\u2010bilirubin score"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-163X","authenticated-orcid":false,"given":"Anthony W H","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C K","family":"Chan","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L H","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China"},{"name":"Institute of Digestive Disease Partner State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W S","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China"},{"name":"Institute of Digestive Disease Partner State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C L","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China"},{"name":"Institute of Digestive Disease Partner State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u2010Fai","family":"To","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong China"},{"name":"Institute of Digestive Disease Partner State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong China"},{"name":"Li Ka Shing Institute of Health Science Sir Y.K. 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