{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:18:46Z","timestamp":1791260326953,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Uppsala University Hospital Research Foundation"},{"name":"Uppsala-\u00d6rebro Regional Research Council"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>To prospectively follow the evolution of hepatobiliary diseases in a population\u2010based cohort of patients with inflammatory bowel diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between 2005 and 2009, 790 incident cases of ulcerative colitis and\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      rohn's disease were registered in the Uppsala Health Region, corresponding to an average incidence of 20.0 and 9.9 new cases\/100\u2009000 inhabitants\/year, respectively. Liver function tests were analyzed in 97.1% and the results of ensuing investigations were summarized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen patients with primary sclerosing cholangitis were diagnosed corresponding to an overall prevalence of 2.2% (ulcerative colitis 1.7% and\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      rohn's disease 3.0%, respectively). The median age at diagnosis was 25 years (interquartile range: 17.0\u201334.0). Among the 92 patients below 17 years of age, three had autoimmune hepatitis and three primary sclerosing cholangitis, summing up to a prevalence of 6.5% immune\u2010mediated hepatobiliary diseases among the pediatric patients. Three patients have undergone liver transplantation and one died of colonic carcinoma. Ten patients have demonstrated persistent elevation of alkaline phosphatases but had a normal magnetic resonance cholangiopancreatography (two patients) or refused further investigation (one patient).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this first large prospective population\u2010based cohort of 526 patients with ulcerative colitis (\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      ) and 264 with\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      rohn's disease, 17 cases of primary sclerosing cholangitis were found, among whom three (17%) so far have been liver transplanted and one has died of colon carcinoma. The average age of those affected by primary sclerosing cholangitis is considerably lower than usually reported. Ten patients had or have had elevated alkaline phosphatase without confirmed liver or biliary disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.12947","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T03:44:11Z","timestamp":1426477451000},"page":"1288-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Appearance of hepatobiliary diseases in a population\u2010based cohort with inflammatory bowel diseases (\n                    <scp>I<\/scp>\n                    nflammatory\n                    <scp>B<\/scp>\n                    owel\n                    <scp>D<\/scp>\n                    isease\n                    <scp>C<\/scp>\n                    ohort of the\n                    <scp>U<\/scp>\n                    ppsala\n                    <scp>R<\/scp>\n                    egion)"],"prefix":"10.1111","volume":"30","author":[{"given":"Anders","family":"R\u00f6nnblom","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mariehamn  \u00c5land Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Tangh\u00f6j","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine M\u00e4lar Hospital  Eskilstuna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Rorsman","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Falu Hospital  Falun Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(65)90018-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-933561"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26565"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166284"},{"key":"e_1_2_6_6_1","first-page":"605","article-title":"Orthotopic liver transplantation for cholestatic diseases","volume":"57","author":"Patkowski W","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.042"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23316"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.05.032"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i4.878"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.072"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.02.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.08.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03756.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.1.84"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)70019-T"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22938"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.046615"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200408000-00014"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.12.009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90308-L"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220511"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181ca4db4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20604"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.10.015"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12947","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T20:06:19Z","timestamp":1696449979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jgh.12947"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12947","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,23]]},"assertion":[{"value":"2015-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}